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Signaling pathways governing the behaviors of leukemia stem cells
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作者 Shirin Azizidoost Ava Nasrolahi +4 位作者 Mohadeseh Sheykhi-Sabzehpoush amir anbiyaiee Seyed Esmaeil Khoshnam Maryam Farzaneh Shahab Uddin 《Genes & Diseases》 SCIE CSCD 2024年第2期830-846,共17页
Leukemia is a malignancy in the blood that develops from the lymphatic system and bone marrow.Although various treatment options have been used for different types of leukemia,understanding the molecular pathways invo... Leukemia is a malignancy in the blood that develops from the lymphatic system and bone marrow.Although various treatment options have been used for different types of leukemia,understanding the molecular pathways involved in the development and progression of leukemia is necessary.Recent studies showed that leukemia stem cells(LSCs)play essential roles in the pathogenesis of leukemia by targeting several signaling pathways,including Notch,Wnt,Hedgehog,and STAT3.LSCs are highly proliferative cells that stimulate tumor initiation,migration,EMT,and drug resistance.This review summarizes cellular pathways that stimulate and prevent LSCs'self-renewal,metastasis,and tumorigenesis. 展开更多
关键词 LEUKEMIA Leukemia stem cells PATHOGENESIS Signaling pathways Stem cells
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