Acute myeloid leukemia(AML)is a heterogeneous clonal disorder of myeloid precursors arrested in their matura-tion,creating a diverse disease entity with a wide range of responses to historically standard treatment app...Acute myeloid leukemia(AML)is a heterogeneous clonal disorder of myeloid precursors arrested in their matura-tion,creating a diverse disease entity with a wide range of responses to historically standard treatment approaches.While signifi cant progress has been made in character-izing and individualizing the disease at diagnosis to op-timally inform those affected,progress in treatment to reduce relapse and induce remission has been limited thus far.In addition to a brief summary of the factors that shape prognostication at diagnosis,this review attempts to expand on the current therapies under investigation that have shown promise in treating AML,including hy-pomethylating agents,gemtuzumab ozogamicin,FLT3 ty-rosine kinase inhibitors,antisense oligonucleotides,and other novel therapies,including aurora kinases,mTOR and PI3 kinase inhibitors,PIM kinase inhibitors,HDAC inhibitors,and IDH targeted therapies.With these,and undoubtedly many others in the future,it is the hope that by combining more accurate prognostication with more effective therapies,patients will begin to have a different,and more complete,outlook on their disease that allows for safer and more successful treatment strategies.展开更多
文摘Acute myeloid leukemia(AML)is a heterogeneous clonal disorder of myeloid precursors arrested in their matura-tion,creating a diverse disease entity with a wide range of responses to historically standard treatment approaches.While signifi cant progress has been made in character-izing and individualizing the disease at diagnosis to op-timally inform those affected,progress in treatment to reduce relapse and induce remission has been limited thus far.In addition to a brief summary of the factors that shape prognostication at diagnosis,this review attempts to expand on the current therapies under investigation that have shown promise in treating AML,including hy-pomethylating agents,gemtuzumab ozogamicin,FLT3 ty-rosine kinase inhibitors,antisense oligonucleotides,and other novel therapies,including aurora kinases,mTOR and PI3 kinase inhibitors,PIM kinase inhibitors,HDAC inhibitors,and IDH targeted therapies.With these,and undoubtedly many others in the future,it is the hope that by combining more accurate prognostication with more effective therapies,patients will begin to have a different,and more complete,outlook on their disease that allows for safer and more successful treatment strategies.
