Design of Hybrid Fuzzy Neural Network for Function Approximation

In this paper, a hybrid Fuzzy Neural Network (FNN) system for function approximation is presented. The proposed FNN can handle numeric and fuzzy inputs simultaneously. The numeric inputs are fuzzified by input nodes upon presentation to the network while the Fuzzy rule based knowledge is translated directly into network architecture. The connections between input to hidden nodes represent rule antecedents and hidden to output nodes represent rule consequents. All the connections are represented by Gaussian fuzzy sets. The method of activation spread in the network is based on a fuzzy mutual subsethood measure. Rule (hidden) node activations are computed as a fuzzy inner product. For a given numeric o fuzzy input, numeric outputs are computed using volume based defuzzification. A supervised learning procedure based on gradient descent is employed to train the network. The model has been tested on two different approximation problems: sine-cosine function approximation and Narazaki-Ralescu function and shows its natural capability of inference, function approximation, and classification.

Helicobacter pylori isolated from gastric juice have higher pathogenic potential than biopsy isolates

Persistent gastritis induced by Helicobacter pylori(H.pylori)is the strongest known risk factor for gastric cancer(GC).H.pylori is prevalent in about 50%world's population,while it causes cancer in less than 2%of exposed individuals.1 Our studies found that H.pylori infection can induce oncogenic properties in AGS cells by deregulating multiple factors associated with the cell cycle,apoptosis,and other important events associated with cancer progression.

Ayurveda and in silico Approach: A Challenging Proficient Confluence for Better Development of Effective Traditional Medicine Spotlighting Network Pharmacology

Coalescence of traditional medicine Ayurveda and in silico technology is a rigor for supplementary development of future-ready effective traditional medicine. Ayurveda is a popular traditional medicine in South Asia, emanating worldwide for the treatment of metabolic disorders and chronic illness. Techniques of in silico biology are not much explored for the investigation of a variety of bioactive phytochemicals of Ayurvedic herbs. Drug repurposing, reverse pharmacology, and polypharmacology in Ayurveda are areas in silico explorations that are needed to understand the rich repertoire of herbs, minerals, herbo-minerals, and assorted Ayurvedic formulations. This review emphasizes exploring the concept of Ayurveda with in silico approaches and the need for Ayurinformatics studies. It also provides an overview of in silico studies done on phytoconstituents of some important Ayurvedic plants, the utility of in silico studies in Ayurvedic phytoconstituents/formulations, limitations/challenges, and prospects of in silico studies in Ayurveda. This article discusses the convergence of in silico work, especially in the least explored field of Ayurveda. The focused coalesce of these two domains could present a predictive combinatorial platform to enhance translational research magnitude. In nutshell, it could provide new insight into an Ayurvedic drug discovery involving an in silico approach that could not only alleviate the process of traditional medicine research but also enhance its effectiveness in addressing health care.