Aging brain becomes susceptible to neurodegenerative diseases due to the shifting of microglia and astrocyte phenotypes to an active“pro-inflammatory”state,causing chronic low-grade neuroinflammation.Despite the fac...Aging brain becomes susceptible to neurodegenerative diseases due to the shifting of microglia and astrocyte phenotypes to an active“pro-inflammatory”state,causing chronic low-grade neuroinflammation.Despite the fact that the role of neuroinflammation during aging has been extensively studied in recent years,the underlying causes remain unclear.The identification of relevant proteins and understanding their potential roles in neuroinflammation can help explain their potential of becoming biomarkers in the aging brain and as drug targets for prevention and treatment.This will eventually reduce the chances of developing neurodegenerative diseases and promote healthier lives in the elderly.In this review,we have summarized the morphological and cellular changes in the aging brain,the effects of age-related neuroinflammation,and the potential role of cofilin-1 during neuroinflammation.We also discuss other factors contributing to brain aging and neuroinflammation.展开更多
Recent emerging research on intestinal microbiota and its contribution to the central nervous system during health and disease has attra cted significant attention.Age-related intestinal microbiota changes initiate br...Recent emerging research on intestinal microbiota and its contribution to the central nervous system during health and disease has attra cted significant attention.Age-related intestinal microbiota changes initiate brain aging and age-related neurodegenerative disorders.Aging is one of the critical predisposing risk factors for the development of neurodegenerative diseases.Maintaining a healthy gut microbiota is essential for a healthy body and aging,but dys biosis could initiate many chro nic diseases.Understanding the underlying mechanisms of gut microbiota alterations/dys biosis will help identify biomarkers for aging-related chro nic conditions.This review summarizes recent advances in micro biota-neurodegenerative disease research and will enhance our unde rstanding of gut microbiota dys biosis and its effects on brain aging.展开更多
基金supported by Fellowship from Saudi Arabia Cultural Mission,College of Pharmacy,Department of Pharmaceutical Chemistry,King Saud University,Riyadh,Saudi Arabia
文摘Aging brain becomes susceptible to neurodegenerative diseases due to the shifting of microglia and astrocyte phenotypes to an active“pro-inflammatory”state,causing chronic low-grade neuroinflammation.Despite the fact that the role of neuroinflammation during aging has been extensively studied in recent years,the underlying causes remain unclear.The identification of relevant proteins and understanding their potential roles in neuroinflammation can help explain their potential of becoming biomarkers in the aging brain and as drug targets for prevention and treatment.This will eventually reduce the chances of developing neurodegenerative diseases and promote healthier lives in the elderly.In this review,we have summarized the morphological and cellular changes in the aging brain,the effects of age-related neuroinflammation,and the potential role of cofilin-1 during neuroinflammation.We also discuss other factors contributing to brain aging and neuroinflammation.
基金the College of Pharmacy,Department of Pharmaceutical Chemistry,King Saud University,Riyadh,Saudi Arabiapartly the grants from The American Heart Association,No.17AIREA33700076/ZAS/2017the National Institute of Neurological Disorders and Stroke of the National Institutes of Health,No.R01NS112642(to ZAS)。
文摘Recent emerging research on intestinal microbiota and its contribution to the central nervous system during health and disease has attra cted significant attention.Age-related intestinal microbiota changes initiate brain aging and age-related neurodegenerative disorders.Aging is one of the critical predisposing risk factors for the development of neurodegenerative diseases.Maintaining a healthy gut microbiota is essential for a healthy body and aging,but dys biosis could initiate many chro nic diseases.Understanding the underlying mechanisms of gut microbiota alterations/dys biosis will help identify biomarkers for aging-related chro nic conditions.This review summarizes recent advances in micro biota-neurodegenerative disease research and will enhance our unde rstanding of gut microbiota dys biosis and its effects on brain aging.
