The developmental origin,anatomical location,and other factors contribute to aortic heterogeneity in a physiological state.On this basis,vascular diseases occur at different ratios based on position specificity,even w...The developmental origin,anatomical location,and other factors contribute to aortic heterogeneity in a physiological state.On this basis,vascular diseases occur at different ratios based on position specificity,even with the same risk factor.However,the continuous intersegmental aortic profile has been rarely reported at the single-cell level.To reveal aortic heterogeneity,we identified 15 cell subtypes from five continuous aortic segments by marker genes and functional definitions.展开更多
基金This work was supported by grants of the National Natural Science Foundation of China(Nos.81970373,31770977,81770442,31400771,82030051,and 81920108003)the Program of Introducing Talents of Discipline to Universities(BP 0719033)+3 种基金the Postdoctoral Science Foundation of China and Shandong Province(Nos.2018M630789 and 201901009)the Shandong Provincial Natural Science Foundation(ZR2020YQ53)the Taishan Scholars Program of Shandong Province(Zhang M.and Zhang C.)the Fundamental Research Funds for the Central Universities(No.2018JC001).
文摘The developmental origin,anatomical location,and other factors contribute to aortic heterogeneity in a physiological state.On this basis,vascular diseases occur at different ratios based on position specificity,even with the same risk factor.However,the continuous intersegmental aortic profile has been rarely reported at the single-cell level.To reveal aortic heterogeneity,we identified 15 cell subtypes from five continuous aortic segments by marker genes and functional definitions.
