Nervous system emerges from complex signaling interactions where extrinsic (neurotransmitters and trophic factors, among others) and intrinsic factors (transcription factors) interplay in the developing tissue to cont...Nervous system emerges from complex signaling interactions where extrinsic (neurotransmitters and trophic factors, among others) and intrinsic factors (transcription factors) interplay in the developing tissue to control gene activity promoting chronic changes in cell genesis, migration, differentiation and death. The retinal microenvironment is regulated by a broad variety of chemicals, including endocannabinoids and nucleotides that modulate embryonic progenitor-neuron-Müller glia signaling in very early developing or pathophysiological conditions.展开更多
基金supported by Coordenaqao de Aperfeigoamento dePessoal de Nivel Superior (CAPES),No.oo1 and PROCAD-2013(both to RAM)Conselho Nacional de Desenvolvimento Cientificoe Tecnologico (CNPq),No.303018/2016-0 (to ALMV)+1 种基金FundacaoCarlos Chagas Filho de Amparo a Pesquisa do Estado do Rio deJaneiro (FAPERJ),No.2016/02 (to GRF)Instituto Nacional de Cienciae Tecnologia de Neurociencia Translacional (INNT/INCT),No.465346/2014-6 (to RAMR).
文摘Nervous system emerges from complex signaling interactions where extrinsic (neurotransmitters and trophic factors, among others) and intrinsic factors (transcription factors) interplay in the developing tissue to control gene activity promoting chronic changes in cell genesis, migration, differentiation and death. The retinal microenvironment is regulated by a broad variety of chemicals, including endocannabinoids and nucleotides that modulate embryonic progenitor-neuron-Müller glia signaling in very early developing or pathophysiological conditions.
