期刊文献+
共找到1篇文章
< 1 >
每页显示 20 50 100
Is leptin related to systemic inflammatory response in acute pancreatitis? 被引量:2
1
作者 Andrés Duarte-Rojo ana lezama-barreda +2 位作者 María Teresa Ramírez-Iglesias Mario Peláez-Luna Guillermo Robles-Díaz 《World Journal of Gastroenterology》 SCIE CAS CSCD 2006年第27期4392-4396,共5页
AIM: To evaluate the relationship between leptin and systemic inflammation in acute pancreatitis. METHODS: Consecutive patients with acute pancreatitis were included. Body mass index and serum samples were obtained ... AIM: To evaluate the relationship between leptin and systemic inflammation in acute pancreatitis. METHODS: Consecutive patients with acute pancreatitis were included. Body mass index and serum samples were obtained at admission. Leptin, TNF-α, IL-6, -8 and -10 levels were determined by ELISA. Severity was defined according to Atlanta criteria. RESULTS: Fifty-two (29 females) patients were studied. Overall body mass index was similar between mild and severe cases, although women with severe pancreatitis had lower body mass index (P = 0.04) and men showed higher body mass index (P = 0.05). No difference was found in leptin levels regarding the severity of pancreatitis, but higher levels tended to appear in male patients with increased body mass index and severe pancreatitis (P = 0.1). A multivariate analysis showed no association between leptin levels and severity. The strongest cytokine associated with severity was IL-6. Correlations of leptin with another cytokines only showed a trend for IL-8 (P = 0.058). CONCLUSION: High body mass index was associated with severity only in males, which may be related to android fat distribution. Serum leptin seems not to play a role on the systemic inflammatory response in acute pancreatitis and its association with severe outcome in males might represent a marker of increased adiposity. 展开更多
关键词 LEPTIN CYTOKINES OBESITY Acute pancreatitis PROGNOSIS
下载PDF
上一页 1 下一页 到第
使用帮助 返回顶部