Objective:To evaluate the correlation between glucose-6-phosphate-dehydrogenase(G6PD) deficiency and neonatal jaundice.Methods:Prospective,observational case-control study was conducted on 490 newborns admitted to Hos...Objective:To evaluate the correlation between glucose-6-phosphate-dehydrogenase(G6PD) deficiency and neonatal jaundice.Methods:Prospective,observational case-control study was conducted on 490 newborns admitted to Hospital de Clinicas de Porto Alegre for phototherapy, who all experienced 35 or more weeks of gestation,from March to December 2007.Enzymatic screening of G6PD activity was performed,followed by PCR.Results:There was prevalence of 4.6% and a boy-girl ratio of 3:1 in jaundiced newborns.No jaundiced neonate with ABO incompatibility presented G6PD deficiency,and no Mediterranean mutation was found.A higher proportion of deficiency was observed in Afro-descendants.There was no association with UGT1A1 variants. Conclusions:G6PD deficiency is not related to severe hyperbilirubinemia and considering the high miscegenation in this area of Brazil,other gene interactions should be investigated.展开更多
基金Supported by FIPE.CnPq.Capes-Reuni and the Postgraduate Program of UFRGS
文摘Objective:To evaluate the correlation between glucose-6-phosphate-dehydrogenase(G6PD) deficiency and neonatal jaundice.Methods:Prospective,observational case-control study was conducted on 490 newborns admitted to Hospital de Clinicas de Porto Alegre for phototherapy, who all experienced 35 or more weeks of gestation,from March to December 2007.Enzymatic screening of G6PD activity was performed,followed by PCR.Results:There was prevalence of 4.6% and a boy-girl ratio of 3:1 in jaundiced newborns.No jaundiced neonate with ABO incompatibility presented G6PD deficiency,and no Mediterranean mutation was found.A higher proportion of deficiency was observed in Afro-descendants.There was no association with UGT1A1 variants. Conclusions:G6PD deficiency is not related to severe hyperbilirubinemia and considering the high miscegenation in this area of Brazil,other gene interactions should be investigated.
