Two-dimensional(2 D)titanium carbide(MXene)nanosheets exhibited excellent conductivity,flexibility,high volumetric capacity,hydrophilic surface,thermal stability,etc.So,it has been exploited in various applications.He...Two-dimensional(2 D)titanium carbide(MXene)nanosheets exhibited excellent conductivity,flexibility,high volumetric capacity,hydrophilic surface,thermal stability,etc.So,it has been exploited in various applications.Herein,we report synthesis of mixed phase 2 D MXene as a catalytic material for simultaneous detection of important biomolecules such as ascorbic acid(AA),dopamine(DA)and uric acid(UA).Crystalline structure,surface morphology and elemental composition of mixed phase titanium carbide(Ti-C-T_(x))MXene(T_(x)=-F,-OH,or-O)nanosheets were confirmed by X-ray diffraction(XRD),Raman spectroscopy,high-resolution transmission electron microscopy(HR-TEM),high-re solution scanning electron microscopy(HR-SEM)and Energy-dispersive X-ray spectroscopy(EDS)mapping analysis.Furthermore,Ti-C-T_(x) modified glassy carbon electrode(GCE)was prepared and its electrochemical properties are studied by cyclic voltammetry(CV)and diffe rential pulse voltammetry(DPV).It was found that Ti-C-T_(x) modified GCE(Ti-C-T_(x)/GCE)showed excellent electrocatalytic activity and separated oxidation peaks of important biomolecules such as AA(at 0.01 V),DA(at 0.21 V)and UA(at 0.33 V).Also,Ti-C-T_(x)/GCE sensor is enabled their simultaneous detection in physiological pH from 100 to 1000μM for AA,0.5-50μM for DA and 0.5-4μM&100-1500μM for UA.The limit of detection’s(LOD)was estimated as 4.6μM,0.06μM and 0.075μM for AA,DA and UA,respectively.Moreover,real sample analysis indicated that spiked AA,DA and UA can be determined accurately by Ti-C-T_(x)/GCE with the recovery ratio in the range between 100.5%-103%in human urine samples.The proposed Ti-C-T_(x) modified electrode exhibited good stability,selectivity and reproducibility as an electrochemical sensor for the detection of AA,DA and UA molecules.展开更多
基金financial support from the Science and Engineering Research Board(SERB),India(No.ECR/2016/001446)Department of Science and Technology(International Bilateral Cooperation Division)for financial support through"INDO-RUSSIA Project(No.INT/RUS/RFBR/385)"。
文摘Two-dimensional(2 D)titanium carbide(MXene)nanosheets exhibited excellent conductivity,flexibility,high volumetric capacity,hydrophilic surface,thermal stability,etc.So,it has been exploited in various applications.Herein,we report synthesis of mixed phase 2 D MXene as a catalytic material for simultaneous detection of important biomolecules such as ascorbic acid(AA),dopamine(DA)and uric acid(UA).Crystalline structure,surface morphology and elemental composition of mixed phase titanium carbide(Ti-C-T_(x))MXene(T_(x)=-F,-OH,or-O)nanosheets were confirmed by X-ray diffraction(XRD),Raman spectroscopy,high-resolution transmission electron microscopy(HR-TEM),high-re solution scanning electron microscopy(HR-SEM)and Energy-dispersive X-ray spectroscopy(EDS)mapping analysis.Furthermore,Ti-C-T_(x) modified glassy carbon electrode(GCE)was prepared and its electrochemical properties are studied by cyclic voltammetry(CV)and diffe rential pulse voltammetry(DPV).It was found that Ti-C-T_(x) modified GCE(Ti-C-T_(x)/GCE)showed excellent electrocatalytic activity and separated oxidation peaks of important biomolecules such as AA(at 0.01 V),DA(at 0.21 V)and UA(at 0.33 V).Also,Ti-C-T_(x)/GCE sensor is enabled their simultaneous detection in physiological pH from 100 to 1000μM for AA,0.5-50μM for DA and 0.5-4μM&100-1500μM for UA.The limit of detection’s(LOD)was estimated as 4.6μM,0.06μM and 0.075μM for AA,DA and UA,respectively.Moreover,real sample analysis indicated that spiked AA,DA and UA can be determined accurately by Ti-C-T_(x)/GCE with the recovery ratio in the range between 100.5%-103%in human urine samples.The proposed Ti-C-T_(x) modified electrode exhibited good stability,selectivity and reproducibility as an electrochemical sensor for the detection of AA,DA and UA molecules.
