Innate intracellular immune programs mediate our first line of defense against virus infection and are dependent on type I interferon （IFNs） [1]. IFNs are cytokines that are produced and secreted from virus-infected...Innate intracellular immune programs mediate our first line of defense against virus infection and are dependent on type I interferon （IFNs） [1]. IFNs are cytokines that are produced and secreted from virus-infected cells. Autocrine and paracrine engagement by IFNs of the type I IFN receptor initiates tissue-wide and systemic signaling through the cellular Jak-STAT pathway to induce the transcription of hundreds of interferon-stimulated genes （ISGs） （Figure 1A）. ISG products confer a variety of functions, including direct antiviral activity, immunomodulatory function, and metabolic control to limit virus infection and promote the adaptive immune resoonse.展开更多
文摘Innate intracellular immune programs mediate our first line of defense against virus infection and are dependent on type I interferon （IFNs） [1]. IFNs are cytokines that are produced and secreted from virus-infected cells. Autocrine and paracrine engagement by IFNs of the type I IFN receptor initiates tissue-wide and systemic signaling through the cellular Jak-STAT pathway to induce the transcription of hundreds of interferon-stimulated genes （ISGs） （Figure 1A）. ISG products confer a variety of functions, including direct antiviral activity, immunomodulatory function, and metabolic control to limit virus infection and promote the adaptive immune resoonse.
