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心脏起搏离子通道的分子结构和功能特性(英文) 被引量:1
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作者 andreas ludwig Franz HOFMANN +2 位作者 宗贤刚 Martin BIEL Martin BIEL 《中国药理学与毒理学杂志》 CAS CSCD 北大核心 2001年第2期81-87,共7页
心脏的起搏受控于一类存在于心脏窦房结被称作If 的离子通道 ,该通道是被细胞膜的超极化所激活 .新近 ,一类被命名为超极化激活及环化核苷酸调控的阳离子 (HCN)通道被克隆 .该家族至少有4个成员 ,即HCN1~HCN4 .其中 2个HCN2和HCN4在心... 心脏的起搏受控于一类存在于心脏窦房结被称作If 的离子通道 ,该通道是被细胞膜的超极化所激活 .新近 ,一类被命名为超极化激活及环化核苷酸调控的阳离子 (HCN)通道被克隆 .该家族至少有4个成员 ,即HCN1~HCN4 .其中 2个HCN2和HCN4在心脏有丰富表达 .用异体表达系统表达克隆的HCN2和HCN4通道蛋白 ,其通道特性类似心脏的天然If 通道 .本综述讨论了HCN通道之间的分子结构差异 。 展开更多
关键词 心脏起搏 离子通道 分子结构 功能特性 超极化激活电流
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Antibacterial Zinc Oxide Nanoparticle Coating of Polyester Fabrics
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作者 Claudia Rode Michael Zieger +6 位作者 Ralf Wyrwa Susanne Thein Cornelia Wiegand Monika Weiser andreas ludwig Dirk Wehner Uta-Christina Hipler 《Journal of Textile Science and Technology》 2015年第2期65-74,共10页
Polyester knitted fabrics have been equipped with antibacterial properties by coating with aqueous suspensions of zinc oxide (ZnO) with different particle diameters. It can be shown that the antibacterial efficacy aga... Polyester knitted fabrics have been equipped with antibacterial properties by coating with aqueous suspensions of zinc oxide (ZnO) with different particle diameters. It can be shown that the antibacterial efficacy against Staphylococcus aureus and Klebsiella pneumonia and the permanence of the coating after defined washing cycles depends on the composition of the ZnO dispersion. To improve the wettability of the textile, the combustion chemical vapor deposition (CCVD) is used to generate a hydrophilic nano layer of a hydroxyl terminated silicon network on the surface of the textiles. The comparison of CCVD-treated and untreated polyester samples does not show differences in the antibacterial activity. The influence of the coating in terms of amount and particle size of ZnO on the viability and proliferation of 3T3 mouse fibroblast cells is examined. A particle content of a maximum of 20 μg ZnO/cm2 is found to be cytocompatible for coating of textiles. 展开更多
关键词 ANTIBACTERIAL TEXTILE ZnO NANOPARTICLES CYTOCOMPATIBILITY
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Influence of the Earth Magnetic Field on Electrically Induced Flows
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作者 Abdellah Kharicha Menghuai Wu +1 位作者 andreas ludwig Ebrahim Karimi Sibaki 《Journal of Iron and Steel Research(International)》 SCIE EI CAS CSCD 2012年第S1期63-66,共4页
The present paper aims at numerical simulation of the intriguing experimental observations made by Bojarevics on the appearance of swirl in flows in an electrically induced flow.Although controlled by poloidal force,t... The present paper aims at numerical simulation of the intriguing experimental observations made by Bojarevics on the appearance of swirl in flows in an electrically induced flow.Although controlled by poloidal force,the flow rotates due to the presence of the earth magnetic field.The bulk flow rotates almost as a whole which indicates that the swirl is generated through a mechanism of"poloidal suppression". 展开更多
关键词 FUNDAMENTAL MHD instability electric SWIRL METALLURGY earth DYNAMO turbulence
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Norton-Hoff model for deformation of growing solid shell of thin slab casting in funnel-shape mold
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作者 Alexander Vakhrushev Abdellah Kharicha +6 位作者 Menghuai Wu andreas ludwig Gerald Nitzl Yong Tang Gernot Hackl Josef Watzinger Christian M.G.Rodrigues 《Journal of Iron and Steel Research(International)》 SCIE EI CSCD 2022年第1期88-102,共15页
A funnel-type mold is commonly used to provide necessary clearance for the submerged entry nozzle in the thin slab casting(TSC).The partially solidified shell is subjected to the mechanical deformations,which can lead... A funnel-type mold is commonly used to provide necessary clearance for the submerged entry nozzle in the thin slab casting(TSC).The partially solidified shell is subjected to the mechanical deformations,which can lead to the defects formation and,as a results,to a breakout.Traditionally,the results of the flow simulation,performed by the finite volume method(FVM),are fed to the external package for the finite element analysis of stress and strain.A coupled model was assembled using“creeping solid”approach by blending the Norton-Hoff viscoplastic stress for the solidifying shell with the Newtonian viscous stress of the liquid melt.The FVM was used to combine both liquid and solid stress models within a single solver.The iterative procedure based on the improved both side diffusion method was introduced to treat the nonlinear relation between the viscoplastic stress and the strain rate.The modeled shell thickness was verified by previously published breakout measurements and the simulation results.Temperature distribution,obtained during the TSC simulation,dominantly corresponds to the viscoplastic range.Developed numerical approach is robust and has direct industrial application. 展开更多
关键词 Solid shell Viscoplastic stress Solidification Norton-Hoff model Thin slab Continuous casting Improved both side diffusion method OpenFOAM
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Correction to: Norton-Hoff model for deformation of growing solid shell of thin slab casting in funnel-shape mold
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作者 Alexander Vakhrushev Abdellah Kharicha +6 位作者 Menghuai Wu andreas ludwig Gerald Nitz Yong Tang Gernot Hackl Josef Watzinger Christian M.G.Rodrigues 《Journal of Iron and Steel Research(International)》 SCIE EI CAS CSCD 2022年第11期1898-1898,共1页
Correction to:J.Iron Steel Res.Int.(2022)29:88-102 https://doi.Org/10.1007/s42243-021-00734-8The original version of this article unfortunately contained mistakes.The assignment of the affiliations was incorrect,and t... Correction to:J.Iron Steel Res.Int.(2022)29:88-102 https://doi.Org/10.1007/s42243-021-00734-8The original version of this article unfortunately contained mistakes.The assignment of the affiliations was incorrect,and the corrected table is given below.The original article has been corrected. 展开更多
关键词 CASTING deformation NORTON
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