一直以来,美国Trace压铸有限公司高度信赖德国机床制造商LICON MT有限两合公司的专业能力,特别是高精度加工新能源电机壳体的机床和工艺。该项目前后历经仅12个月,目前四台双主轴柔性加工中心LiFLEX II 766 i³已经投入生产,第五台...一直以来,美国Trace压铸有限公司高度信赖德国机床制造商LICON MT有限两合公司的专业能力,特别是高精度加工新能源电机壳体的机床和工艺。该项目前后历经仅12个月,目前四台双主轴柔性加工中心LiFLEX II 766 i³已经投入生产,第五台机床正在发运当中。凭借卓越的加工精度和极快的加工节拍,这些德国设备的性能已经远远超出美国客户的期望。展开更多
Meiotic drivers distort transmission to the next generation in their favor, with detrimental effects on the fitness of their homologues and the rest of the genome. Male carriers of meiotic drivers commonly inflict cos...Meiotic drivers distort transmission to the next generation in their favor, with detrimental effects on the fitness of their homologues and the rest of the genome. Male carriers of meiotic drivers commonly inflict costs on their mates through genetic incompatibility, reduced fecundity, or biased brood sex ratios. Given these costs, evidence for female discrimination against male carriers is surprisingly rare. One of few examples is the t haplotype in house mice, a meiotic driver that shows strong transmission distortion in males and is typically homozygote lethal. As a consequence, mating between 2 t heterozygous （＋/t） mice leads to high embryo mortality. Previous experiments showing that＋/t females avoid this incompatibility cost by preferring ＋/＋ versus ＋/t males have inferred preference based on olfactory cues or brief social interactions. Evidence from mating contexts in laboratory settings and semi-natural populations has been inconclusive. Here, we investigated female choice from a large number of no-choice mating trials. We found no evidence for discrimination against＋/t males based on mating, remating, and copulatory behavior. Further, we found no evidence for avoidance of incompatibility through selective interactions between game- tes. The likelihood of mating showed significant effects of female weight and genotype, suggesting that our test paradigm enabled females to exhibit mate choice. We discuss the strengths and limitations of our approach. By explicitly considering selection at both the individual and gene level, we argue why precopulatory female discrimination by＋/t females may be less evolutionarily stable than discrimination by all females based on postcopulatory mechanisms.展开更多
文摘一直以来,美国Trace压铸有限公司高度信赖德国机床制造商LICON MT有限两合公司的专业能力,特别是高精度加工新能源电机壳体的机床和工艺。该项目前后历经仅12个月,目前四台双主轴柔性加工中心LiFLEX II 766 i³已经投入生产,第五台机床正在发运当中。凭借卓越的加工精度和极快的加工节拍,这些德国设备的性能已经远远超出美国客户的期望。
基金Acknowledgments We thank Jari Garbely for DNA extraction and genotyping, Gabi Stichel and Sally Steinert for assistance with animal husbandry, Kerstin Musolf for advice on oestrus stage determination, and Barbara Konig for support. We also thank Andri Manser for helpful discussions and Laura Travers and 2 anonymous reviewers for comments on earlier versions of the manuscript.This study was supported by the Swiss National Science Foundation Grant 138389.
文摘Meiotic drivers distort transmission to the next generation in their favor, with detrimental effects on the fitness of their homologues and the rest of the genome. Male carriers of meiotic drivers commonly inflict costs on their mates through genetic incompatibility, reduced fecundity, or biased brood sex ratios. Given these costs, evidence for female discrimination against male carriers is surprisingly rare. One of few examples is the t haplotype in house mice, a meiotic driver that shows strong transmission distortion in males and is typically homozygote lethal. As a consequence, mating between 2 t heterozygous （＋/t） mice leads to high embryo mortality. Previous experiments showing that＋/t females avoid this incompatibility cost by preferring ＋/＋ versus ＋/t males have inferred preference based on olfactory cues or brief social interactions. Evidence from mating contexts in laboratory settings and semi-natural populations has been inconclusive. Here, we investigated female choice from a large number of no-choice mating trials. We found no evidence for discrimination against＋/t males based on mating, remating, and copulatory behavior. Further, we found no evidence for avoidance of incompatibility through selective interactions between game- tes. The likelihood of mating showed significant effects of female weight and genotype, suggesting that our test paradigm enabled females to exhibit mate choice. We discuss the strengths and limitations of our approach. By explicitly considering selection at both the individual and gene level, we argue why precopulatory female discrimination by＋/t females may be less evolutionarily stable than discrimination by all females based on postcopulatory mechanisms.
