Human endogenous retrovirus type-W and multiple sclerosis–related smoldering neuroinflammation

Introduction to human endogenous retrovirus type-W(HERV-W): Genomic inheritance from the past includes retroviral sequences that have been stably incorporated into our genomes and account for up to 8% of human DNA.

GPGPU-parallelised hybrid finite-discrete element modelling of rock chipping and fragmentation process in mechanical cutting

Mechanical cutting provides one of the most flexible and environmentally friendly excavation methods.It has attracted numerous efforts to model the rock chipping and fragmentation process,especially using the explicit finite element method(FEM) and bonded particle model(BPM),in order to improve cutting efficiency.This study investigates the application of a general-purpose graphic-processing-unit parallelised hybrid finite-discrete element method(FDEM) which enjoys the advantages of both explicit FEM and BPM,in modelling the rock chipping and fragmentation process in the rock scratch test of mechanical rock cutting.The input parameters of FDEM are determined through a calibration procedure of modelling conventional Brazilian tensile and uniaxial compressive tests of limestone,A series of scratch tests with various cutting velocities,cutter rake angles and cutting depths is then modelled using FDEM with calibrated input parameters.A few cycles of cutter/rock interactions,including their engagement and detachment process,are modelled for each case,which is conducted for the first time to the best knowledge of the authors,thanks to the general purpose graphic processing units(GPGPU) parallelisation.The failure mechanism,cutting force,chipping morphology and effect of various factors on them are discussed on the basis of the modelled results.Finally,it is concluded that GPGPU-parallelised FDEM provides a powerful tool to further study rock cutting and improve cutting efficiencies since it can explicitly capture different fracture mechanisms contributing to the rock chipping as well as chip formation and the separation process in mechanical cutting.Moreover,it is concluded that chipping is mostly owed to the mix-mode Ⅰ-Ⅱ fracture in all cases although mode Ⅱ cracks and mode Ⅰ cracks are the dominant failures in rock cutting with shallow and deep cutting depths,respectively.The chip morphology is found to be a function of cutter velocdty,cutting depth and cutter rake angle.

Comparison of SCS and Green-Ampt Methods in Surface Runoff-Flooding Simulation for Klang Watershed in Malaysia

The main aim in this research is comparison the parameters of some storm events in the watershed using two loss models in Unit hydrograph method by HEC-HMS. SCS Curve Number and Green-Ampt methods by developing loss model as a major component in runoff and flood modeling. The study is conducted in the Kuala Lumpurwatershed with674 km2 area located in Klang basin inMalaysia. The catchment delineation is generated for the Klang watershed to get sub-watershed parameters by using HEC-GeoHMS extension in ARCGIS. Then all the necessary parameters are assigned to the models applied in this study to run the runoff and flood model. The results showed that there was no significant difference between the SCS-CN and Green-Ampt loss method applied in the Klang watershed. Estimated direct runoff and Peak discharge (r = 0.98) indicates a statistically positive correlations between the results of the study. And also it has been attempted to use objective functions in HEC-HMS (percent error peaks and percent error volume) to classify the methods. The selection of best method is on the base of considering least difference between the results of simulation to observed events in hydrographs so that it can address which model is suit for runoff-flood simulation in Klang watershed. Results showed that SCS CN and Green-Ampt methods, in three events by fitting with percent error in peak and percent error in volume had no significant difference.

Anticoagulation and antiplatelet management in gastrointestinal endoscopy: A review of current evidence

The role of endoscopic procedures,in both diagnostic and therapeutic purposes is continually expanding and evolving rapidly.In this context,endoscopists will encounter patients prescribed on anticoagulant and antiplatelet medications frequently.This poses an increased risk of intraprocedural and delayed gastrointestinal bleeding.Thus,there is now greater importance on optimal pre,peri and post-operative management of anticoagulant and/or antiplatelet therapy to minimise the risk of post-procedural bleeding,without increasing the risk of a thromboembolic event as a consequence of therapy interruption.Currently,there are position statements and guidelines from the major gastroenterology societies.These are available to assist endoscopists with an evidenced-based systematic approach to anticoagulant and/or antiplatelet management in endoscopic procedures,to ensure optimal patient safety.However,since the publication of these guidelines,there is emerging evidence not previously considered in the recommendations that may warrant changes to our current clinical practices.Most notably and divergent from current position statements,is a growing concern regarding the use of heparin bridging therapy during warfarin cessation and its associated risk of increased bleeding,suggestive that this practice should be avoided.In addition,there is emerging evidence that anticoagulant and/or antiplatelet therapy may be safe to be continued in cold snare polypectomy for small polyps(<10 mm).

A 2D DEM-LBM study on soil behaviour due to locally injected fluid

Leakage from underground pipes could result in foundations being undermined and cause damage to adjacent infrastructure. Soil particles surrounding the leaking area could be mobilised, displaced, and even washed out of the soil matrix by the leaking fluid, generating a void or cavity. A two-dimensional simulation using a coupled discrete element method and lattice Boltzmann method （DEM-LBM） has been used to investigate the behaviour of a soil bed subject to a locally injected fluid, which represents a leak in a pipe. Various values of inter-particle surface energy were also adopted to model the mechanical effects of cohesive particles. The results suggest that the inter-particle surface energy greatly influences the bed response with respect to the leaking fluid, including the excess pressure initiating the cavity, the cavity shape and its evolution rate.