Arene C(sp^(2))-H bond borylation offers direct and efficient access to aryl boronic esters.Using in situ catalyst activation and photoirradiation,the iron-catalysed C(sp^(2))-H borylation reaction of carboarenes,pyrr...Arene C(sp^(2))-H bond borylation offers direct and efficient access to aryl boronic esters.Using in situ catalyst activation and photoirradiation,the iron-catalysed C(sp^(2))-H borylation reaction of carboarenes,pyrroles,and indoles has been developed using only bench-stable pre-catalysts and reagents.Good functional group tolerance was observed including those not reported using previous methods(ArNH_(2),ArOH,ArSiR_(3),ArP(O)(O)_(2),ArC(O)NR_(2)).Mechanistic studies revealed iron-catalysed reductive deoxygenation,C—F protodefluorination,and a demethylation of aryl methyl ethers by C—O sigma bond hydroboration.展开更多
基金S.P.T.thanks The Royal Society for a University Research Fel-lowship(RF191015)J.H.D.and S.P.T.acknowledge GSK and EPSRC(110002)The Royal Society(RF191015)for postdoctoral funding.L.B.acknowledges The Royal Society and The University of Edinburgh for a Ph.D.studentship(RF191015).
文摘Arene C(sp^(2))-H bond borylation offers direct and efficient access to aryl boronic esters.Using in situ catalyst activation and photoirradiation,the iron-catalysed C(sp^(2))-H borylation reaction of carboarenes,pyrroles,and indoles has been developed using only bench-stable pre-catalysts and reagents.Good functional group tolerance was observed including those not reported using previous methods(ArNH_(2),ArOH,ArSiR_(3),ArP(O)(O)_(2),ArC(O)NR_(2)).Mechanistic studies revealed iron-catalysed reductive deoxygenation,C—F protodefluorination,and a demethylation of aryl methyl ethers by C—O sigma bond hydroboration.
