期刊文献+
共找到1篇文章
< 1 >
每页显示 20 50 100
Arctostaphylos uva-ursi L.leaves extract and its modified cysteine preparation for the management of insulin resistance:chemical analysis and bioactivity
1
作者 Ganna Kravchenko Oksana Krasilnikova +5 位作者 Ain Raal Matar Mazen Natalia Chaika Igor Kireyev andriy grytsyk Oleh Koshovyi 《Natural Products and Bioprospecting》 2022年第1期427-441,共15页
Bearberry(Arctostaphylos uva-ursi L.)is a perennial plant of the heather family(Ericaceae).The leaves are dominated by arbutin,phenol carbonic acids flavonoids,saponins,etc.It was previously shown that the bearberry l... Bearberry(Arctostaphylos uva-ursi L.)is a perennial plant of the heather family(Ericaceae).The leaves are dominated by arbutin,phenol carbonic acids flavonoids,saponins,etc.It was previously shown that the bearberry leaves extract reduced blood glucose level in healthy animals under glucose overload,so it need to be studied more detail.The aim of the study was to investigate the chemical composition and the effect of dry alcohol extract from bearberry leaves,which enriched with cysteine,on the rats pancreas under experimental dexamethasone-induced insulin resistance(IR).Arctostaphylos uva-ursi L.leaves extract and its modified cysteine preparation were obtained according to the developed method with 50%ethanol solution.Their phytochemical profile,hypoglycaemic and pancreatic protective effect were investigated.Phenologlycoside(arbutin),phenolic carboxylic acid(gallic acid),5 flavonoids and 4 hydroxy-cinnamic acids were identified and quantified in the extracts by HPLC.Present data revealed that bearberry leaves alcoholic dry extract enriched with cysteine has a hypoglycaemic and pancreatic protective effect in treated animals under dexamethasone-induced IR model.Treatment improved hyperglycaemia,insulin resistance and beta cell reduc-tion induced by dexamethasone injections. 展开更多
关键词 Arctostaphylos uva-ursi L. EXTRACT Hypoglycaemic activity LEAVES Phenolic substances
下载PDF
上一页 1 下一页 到第
使用帮助 返回顶部