The present review summarizes the prevalence and active clinical problems in obese patients with Helicobacter pylori(H.pylori)infection,as well as the outcomes after bariatric surgery in this patient population.The in...The present review summarizes the prevalence and active clinical problems in obese patients with Helicobacter pylori(H.pylori)infection,as well as the outcomes after bariatric surgery in this patient population.The involvement of H.pylori in the pathophysiology of obesity is still debated.It may be that the infection is protective against obesity,because of the gastritis-induced decrease in production and secretion of the orexigenic hormone ghrelin.However,recent epidemiological studies have failed to show an association between H.pylori infection and reduced body mass index.H.pylori infection might represent a limiting factor in the access to bariatric bypass surgery,even if highquality evidence indicating the advantages of preoperative H.pylori screening and eradication is lacking.The clinical management of infection is complicated by the lower eradication rates with standard therapeutic regimens reported in obese patients than in the normalweight population.Prospective clinical studies to ameliorate both H.pylori eradication rates and control the clinical outcomes of H.pylori infection after different bariatric procedures are warranted.展开更多
Introduction Gastrointestinal stromal tumors(GISTs)are neoplasms arising from mesenchymal cells localized into the muscularis propria of the gastrointestinal(GI)tract[1];5%of GISTs are extra-GISTs(EGISTs),as they diff...Introduction Gastrointestinal stromal tumors(GISTs)are neoplasms arising from mesenchymal cells localized into the muscularis propria of the gastrointestinal(GI)tract[1];5%of GISTs are extra-GISTs(EGISTs),as they differently originate from adipose tissue adjacent to the GI tract(omentum and mesentery)or from the pancreas[2].So far,both GISTs and EGISTs have been managed indistinctively by combining surgery,histopathological distinctive features,imaging,and molecular analysis.Moreover.展开更多
基金Supported by University Sapienza 000324_2012_AR_SEVERI-SEVERI-PROGETTO RICERCA SAPIENZA 2012
文摘The present review summarizes the prevalence and active clinical problems in obese patients with Helicobacter pylori(H.pylori)infection,as well as the outcomes after bariatric surgery in this patient population.The involvement of H.pylori in the pathophysiology of obesity is still debated.It may be that the infection is protective against obesity,because of the gastritis-induced decrease in production and secretion of the orexigenic hormone ghrelin.However,recent epidemiological studies have failed to show an association between H.pylori infection and reduced body mass index.H.pylori infection might represent a limiting factor in the access to bariatric bypass surgery,even if highquality evidence indicating the advantages of preoperative H.pylori screening and eradication is lacking.The clinical management of infection is complicated by the lower eradication rates with standard therapeutic regimens reported in obese patients than in the normalweight population.Prospective clinical studies to ameliorate both H.pylori eradication rates and control the clinical outcomes of H.pylori infection after different bariatric procedures are warranted.
文摘Introduction Gastrointestinal stromal tumors(GISTs)are neoplasms arising from mesenchymal cells localized into the muscularis propria of the gastrointestinal(GI)tract[1];5%of GISTs are extra-GISTs(EGISTs),as they differently originate from adipose tissue adjacent to the GI tract(omentum and mesentery)or from the pancreas[2].So far,both GISTs and EGISTs have been managed indistinctively by combining surgery,histopathological distinctive features,imaging,and molecular analysis.Moreover.