To investigate sources of Salmonella pullorum infections that cause frequent outbreaks of bacillary white diarrhea in poultry and sporadic human food poisoning in Nigeria, prevalence of the infection among day-old-chi...To investigate sources of Salmonella pullorum infections that cause frequent outbreaks of bacillary white diarrhea in poultry and sporadic human food poisoning in Nigeria, prevalence of the infection among day-old-chicks in Akwa-Ibom State, south-south Nigeria, was studied. From each depot/hatchery, 30 day-old chicks were randomly selected for their livers, spleens, kidneys, hearts, yolk sacs and intestines which were processed and cultured on appropriate bacterial media. Colonies that grew from the specimens were characterized based on their morphologies, staining characteristics, biochemical reactions and cultural characteristics. Gram positive isolates that were: short, plum shaped, rods, non-spore forming and non-capsulated were identified as Salmonella species. Motility test and biochemical tests on the Salmonella colonies identified those that were S. pullorum. Five percent of chicks being distributed in Akwa-Ibom State, Nigeria were infected with S. pullorum, the agent of, bacillary white diarrhea (which causes high mortality in chicks) and food poisoning in man.展开更多
To restore efficacy (≥95% infection-reduction) to drugs against resistant infections (now, posing a bigger medical challenge, globally, than even HIV/AIDS), Cotrimoxazole was formulated with a synthetic Aluminum-magn...To restore efficacy (≥95% infection-reduction) to drugs against resistant infections (now, posing a bigger medical challenge, globally, than even HIV/AIDS), Cotrimoxazole was formulated with a synthetic Aluminum-magnesium silicate (Medicinal mineral which molecules are made of Nanoparticles, that is already in use as pharmaceutical-stabilizing agent) and used with antioxidants to treat Cotrimoxazole-resistant Salmonella pulorum infected chicks. Chick-groups A, B and C were fed antioxidants-fortified feed while groups D, E, F, G and H were not. The treatment-groups and their Cotrimoxazole doses/formulations were: A and D (100%/MSAMS-Cotrimoxazole);B and E (75%/MSAMS-Cotrimoxazole);C and F (50%/MSAMS-Cotrimoxazole) and G (100%/Cotrimoxazole). Infection-reductions (96.23% and 94.98%) of the groups of 75%/MSAMS-Cotrimoxazole/antioxidants and 75%/MSAMS-Cotrimoxazole were significantly (P ≤ 0.05) better than 76.99% (100%/Cotrimoxazole);10.04% (50%/MSAMS-Cotrimoxazole/antioxidants);1.60% (50%/MSAMS-Cotrimoxazole);−212.60% (100%/MSAMS-Cotrimoxazole/antioxidants) and −230.96% (100%/MSAMS-Cotrimoxazole).展开更多
文摘To investigate sources of Salmonella pullorum infections that cause frequent outbreaks of bacillary white diarrhea in poultry and sporadic human food poisoning in Nigeria, prevalence of the infection among day-old-chicks in Akwa-Ibom State, south-south Nigeria, was studied. From each depot/hatchery, 30 day-old chicks were randomly selected for their livers, spleens, kidneys, hearts, yolk sacs and intestines which were processed and cultured on appropriate bacterial media. Colonies that grew from the specimens were characterized based on their morphologies, staining characteristics, biochemical reactions and cultural characteristics. Gram positive isolates that were: short, plum shaped, rods, non-spore forming and non-capsulated were identified as Salmonella species. Motility test and biochemical tests on the Salmonella colonies identified those that were S. pullorum. Five percent of chicks being distributed in Akwa-Ibom State, Nigeria were infected with S. pullorum, the agent of, bacillary white diarrhea (which causes high mortality in chicks) and food poisoning in man.
文摘To restore efficacy (≥95% infection-reduction) to drugs against resistant infections (now, posing a bigger medical challenge, globally, than even HIV/AIDS), Cotrimoxazole was formulated with a synthetic Aluminum-magnesium silicate (Medicinal mineral which molecules are made of Nanoparticles, that is already in use as pharmaceutical-stabilizing agent) and used with antioxidants to treat Cotrimoxazole-resistant Salmonella pulorum infected chicks. Chick-groups A, B and C were fed antioxidants-fortified feed while groups D, E, F, G and H were not. The treatment-groups and their Cotrimoxazole doses/formulations were: A and D (100%/MSAMS-Cotrimoxazole);B and E (75%/MSAMS-Cotrimoxazole);C and F (50%/MSAMS-Cotrimoxazole) and G (100%/Cotrimoxazole). Infection-reductions (96.23% and 94.98%) of the groups of 75%/MSAMS-Cotrimoxazole/antioxidants and 75%/MSAMS-Cotrimoxazole were significantly (P ≤ 0.05) better than 76.99% (100%/Cotrimoxazole);10.04% (50%/MSAMS-Cotrimoxazole/antioxidants);1.60% (50%/MSAMS-Cotrimoxazole);−212.60% (100%/MSAMS-Cotrimoxazole/antioxidants) and −230.96% (100%/MSAMS-Cotrimoxazole).
