Background: Prognosis in Mucormycosis is poor, secondary to the nature of such opportunistic angioinvasive fungal infection that affects immuno-compromised patients with uncontrolled diabetes which is a common risk fa...Background: Prognosis in Mucormycosis is poor, secondary to the nature of such opportunistic angioinvasive fungal infection that affects immuno-compromised patients with uncontrolled diabetes which is a common risk factors in most of the cases. Objectives: Patients with post-Covid Mucormycosis presenting to the ENT OPD were included and evaluated for HbA1c, extent of disease, and subsequently underwent the required modality of management. Methods: A prospective observational study was done in 154 patients of mucormycosis and according to the extent of disease such as sinonasal involvement, orbital extension or intracranial extension, the HbA1c values were compared among themselves. Results: In our study, out of 154 patients, 86 (55.8%) patients have only sinonasal involvement, 30 (19.4%) patients have extension into orbit and 38 (24.6%) patients have intracranial spread. In patients with sinonasal involvement, mean HbA1c was 9.8 ± 2.41;in orbital extension, mean HbA1c was 12.7 ± 2.31 and in intracranial extension, mean HbA1c was 13.4 ± 1.98. Conclusion: In our study, elevated HbA1c is indicative of poor glycaemic control and positively correlated with increased invasiveness and aggressive fungal disease.展开更多
Background: Oral cavity malignancy can result from surface epithelium, salivary glands, or submucosal soft tissue. Common symptoms may include non-healing ulcers, slurred speech, dysphagia, neck mass and pain which ma...Background: Oral cavity malignancy can result from surface epithelium, salivary glands, or submucosal soft tissue. Common symptoms may include non-healing ulcers, slurred speech, dysphagia, neck mass and pain which may indicate cortical invasion. Morbidity and quality of life have been seen to rise with mandibular excision in oral cavity squamous cell carcinoma. Therefore, in order to design the surgery appropriately, it is vital to be aware of the mandibular invasion prior to the procedure. Various researches have been focused on the accuracy of clinical examination and imaging technique in predicting tumour invasion of the mandible in oral malignancy. The goal of this study was to find a correlation between histological assessment, clinical examination, and computed tomography results in patients with mandibular involvement and oral cavity squamous cell carcinoma. Objectives: To determine the sensitivity, specificity, NPV and PPV of CECT and clinical diagnosis in patients with oral squamous cell carcinoma with mandibular invasion. Methods: A cross-sectional observational study was set out to review preoperative clinical and radiological assessment;and post operative histopathological finding of mandibular resection specimen in clinically evaluated and diagnosed cases of oral cavity squamous cell carcinoma (SCC) with mandibular invasion. Results: 43 individuals of oral cavity SCC with mandibular involvement were examined. 12 out of 28 mandibular resections had bone invasion, with numerous tumour entry sites being the most frequent mechanism of invasion, according to post-operative HPE. The positive predictive value (PPV) of contrast enhanced computerised tomography (CECT) scans was 42.8%, as 28 individuals had invasions revealed;sensitivity is almost 100%;specificity is 48.3. Conclusion: Prioritizing the identification of mandibular invasion is essential to enhance the prognosis of patients with oral SCC. There is an urgent necessity to review the usefulness of radiology in the treatment of mandibulectomy. Combination of clinical and radiological examination increases sensitivity and specificity.展开更多
文摘Background: Prognosis in Mucormycosis is poor, secondary to the nature of such opportunistic angioinvasive fungal infection that affects immuno-compromised patients with uncontrolled diabetes which is a common risk factors in most of the cases. Objectives: Patients with post-Covid Mucormycosis presenting to the ENT OPD were included and evaluated for HbA1c, extent of disease, and subsequently underwent the required modality of management. Methods: A prospective observational study was done in 154 patients of mucormycosis and according to the extent of disease such as sinonasal involvement, orbital extension or intracranial extension, the HbA1c values were compared among themselves. Results: In our study, out of 154 patients, 86 (55.8%) patients have only sinonasal involvement, 30 (19.4%) patients have extension into orbit and 38 (24.6%) patients have intracranial spread. In patients with sinonasal involvement, mean HbA1c was 9.8 ± 2.41;in orbital extension, mean HbA1c was 12.7 ± 2.31 and in intracranial extension, mean HbA1c was 13.4 ± 1.98. Conclusion: In our study, elevated HbA1c is indicative of poor glycaemic control and positively correlated with increased invasiveness and aggressive fungal disease.
文摘Background: Oral cavity malignancy can result from surface epithelium, salivary glands, or submucosal soft tissue. Common symptoms may include non-healing ulcers, slurred speech, dysphagia, neck mass and pain which may indicate cortical invasion. Morbidity and quality of life have been seen to rise with mandibular excision in oral cavity squamous cell carcinoma. Therefore, in order to design the surgery appropriately, it is vital to be aware of the mandibular invasion prior to the procedure. Various researches have been focused on the accuracy of clinical examination and imaging technique in predicting tumour invasion of the mandible in oral malignancy. The goal of this study was to find a correlation between histological assessment, clinical examination, and computed tomography results in patients with mandibular involvement and oral cavity squamous cell carcinoma. Objectives: To determine the sensitivity, specificity, NPV and PPV of CECT and clinical diagnosis in patients with oral squamous cell carcinoma with mandibular invasion. Methods: A cross-sectional observational study was set out to review preoperative clinical and radiological assessment;and post operative histopathological finding of mandibular resection specimen in clinically evaluated and diagnosed cases of oral cavity squamous cell carcinoma (SCC) with mandibular invasion. Results: 43 individuals of oral cavity SCC with mandibular involvement were examined. 12 out of 28 mandibular resections had bone invasion, with numerous tumour entry sites being the most frequent mechanism of invasion, according to post-operative HPE. The positive predictive value (PPV) of contrast enhanced computerised tomography (CECT) scans was 42.8%, as 28 individuals had invasions revealed;sensitivity is almost 100%;specificity is 48.3. Conclusion: Prioritizing the identification of mandibular invasion is essential to enhance the prognosis of patients with oral SCC. There is an urgent necessity to review the usefulness of radiology in the treatment of mandibulectomy. Combination of clinical and radiological examination increases sensitivity and specificity.
