A Co-based metal-organic framework （Co-MOF） with a unique three-dimensional starfish-like nanostructure was successfully synthesized using a simple ultrasonic method. After subsequent carbonization and oxidation, a ...A Co-based metal-organic framework （Co-MOF） with a unique three-dimensional starfish-like nanostructure was successfully synthesized using a simple ultrasonic method. After subsequent carbonization and oxidation, a nanocomposite of nitrogen-doped carbon with a Co3O4 coating （Co3O4@N-C） with a porous starfish-like nanostructure was obtained. The final hybrid exhibited excellent lithium storage performance when evaluated as an anode material in a lithiumion battery. A remarkable and stable discharge capacity of 795 mAh·g^-1 was maintained at 0.5 A·g^-1 after 300 cycles. Excellent rate capability was also obtained. In addition, a full Co3O4@N-C/LiFePO4 battery displayed stable capacity retention of 95% after 100 cycles. This excellent lithium storage performance is attributed to the unique porous starfish-like structure, which effectively buffers the volume expansion that occurs during Li^＋ insertion/deinsertion. Meanwhile, the nitrogendoped carbon coating enhances the electrical conductivity and provides a buffer layer to accommodate the volume change and accelerate the formation of a stable solid electrolyte interface layer.展开更多
To combine localized drug release with multimodal therapy for malignant tumor, a composite hydrogel as an integrative drug delivery system was facilely prepared. The system contains spinach extract （SE）, reduced gra...To combine localized drug release with multimodal therapy for malignant tumor, a composite hydrogel as an integrative drug delivery system was facilely prepared. The system contains spinach extract （SE）, reduced graphene oxide （rGO） and gold nanocages （AuNCs）. SE conduces to the formation of hydrogel, and also serves as a green material for improving the biocompatibility of hydrogel, and a natural pho- tosensitizer for killing tumor cells under laser radiation （fi60 nm）. AuNts show obvious photothermy and can enhance the generation of cytotoxic singlet oxygen （102）. The composite hydrogel shell on tumor cells exhibits several competitive advantages including enhanced antitumor effect by retaining the high con- centration of drugs around cancer cell, excellent PDT/FFr compatibility as well as high loading and controllable release of fluorouracil （5-FU） for synergetic multimodal treatment. The survival rate of HeLa cells incubated with 5-FU loaded hydrogel under NIR radiation for 10 min sharply decreases to 1.2%, in- dicating remarkably improved antitumor effects. These results demonstrate that the hydrogel is an excellent delivery carrier for localizable, NIR-responsive and combined PTT/PDT/Chemo synergetic antitumor.展开更多
基金Acknowledgements This work is supported by the National Natural Science Foundation of China （Nos. 21173001 and 21371003） and Anhui Province Key Laboratory of Environment-Friendly Polymer Materials.
文摘A Co-based metal-organic framework （Co-MOF） with a unique three-dimensional starfish-like nanostructure was successfully synthesized using a simple ultrasonic method. After subsequent carbonization and oxidation, a nanocomposite of nitrogen-doped carbon with a Co3O4 coating （Co3O4@N-C） with a porous starfish-like nanostructure was obtained. The final hybrid exhibited excellent lithium storage performance when evaluated as an anode material in a lithiumion battery. A remarkable and stable discharge capacity of 795 mAh·g^-1 was maintained at 0.5 A·g^-1 after 300 cycles. Excellent rate capability was also obtained. In addition, a full Co3O4@N-C/LiFePO4 battery displayed stable capacity retention of 95% after 100 cycles. This excellent lithium storage performance is attributed to the unique porous starfish-like structure, which effectively buffers the volume expansion that occurs during Li^＋ insertion/deinsertion. Meanwhile, the nitrogendoped carbon coating enhances the electrical conductivity and provides a buffer layer to accommodate the volume change and accelerate the formation of a stable solid electrolyte interface layer.
基金supported by the National Natural Science Foundation of China (Nos. 21171001, 51372004, 21571002 and 21371003)the Anhui Province Key Laboratory of Environmentfriendly Polymer Materials+1 种基金the Anhui Provincial College Student Innovation Fund Project (No. 201510375048)Key Project of the Natural Science Foundation of the Provincial Education Department (No. KJ2016A679)
文摘To combine localized drug release with multimodal therapy for malignant tumor, a composite hydrogel as an integrative drug delivery system was facilely prepared. The system contains spinach extract （SE）, reduced graphene oxide （rGO） and gold nanocages （AuNCs）. SE conduces to the formation of hydrogel, and also serves as a green material for improving the biocompatibility of hydrogel, and a natural pho- tosensitizer for killing tumor cells under laser radiation （fi60 nm）. AuNts show obvious photothermy and can enhance the generation of cytotoxic singlet oxygen （102）. The composite hydrogel shell on tumor cells exhibits several competitive advantages including enhanced antitumor effect by retaining the high con- centration of drugs around cancer cell, excellent PDT/FFr compatibility as well as high loading and controllable release of fluorouracil （5-FU） for synergetic multimodal treatment. The survival rate of HeLa cells incubated with 5-FU loaded hydrogel under NIR radiation for 10 min sharply decreases to 1.2%, in- dicating remarkably improved antitumor effects. These results demonstrate that the hydrogel is an excellent delivery carrier for localizable, NIR-responsive and combined PTT/PDT/Chemo synergetic antitumor.
