Studies reporting the Indian prevalence of Epidermal Growth Factor Receptor (EGFR) mutation are mostly single centers with small sample sizes. This systematic review and meta-analysis summarized the available evidence...Studies reporting the Indian prevalence of Epidermal Growth Factor Receptor (EGFR) mutation are mostly single centers with small sample sizes. This systematic review and meta-analysis summarized the available evidence of EGFR mutation epidemiology in Indian patients with adenocarcinoma (ADC) Non-Small Cell Lung Cancer (NSCLC). We conducted a structured literature search in PubMed, and EMBASE databases from January 2004 through October 2019. The primary outcome of interest was prevalence of EGFR mutation by gender, smoking status, and mutation subtype. The review included 34 studies. EGFR mutation prevalence was 39.5% in patients with ADC, and significantly higher in females, non-smokers, and patients with exon 19 deletions. The EGFR mutation frequency in Indian patients with ADC was higher than reported in Caucasians but at a lower range of that reported in East Asians. These findings support the use of EGFR mutation testing to guide choice of treatment.展开更多
The synthesis and catalytic properties of copper nanoparticles（Cunps） were reported using L-ascorbic acid as reducing and capping agent in aqueous medium. The effect of different concentrations of L-ascorbic acid on...The synthesis and catalytic properties of copper nanoparticles（Cunps） were reported using L-ascorbic acid as reducing and capping agent in aqueous medium. The effect of different concentrations of L-ascorbic acid on the particle size of Cunps was investigated. The synthesized Cunps were characterized by UV-Visible spectrophotometer, scanning electron microscopy（SEM）, transmission electron microscopy（TEM） and Fourier transform infrared（FTIR） spectrophotometer. The result indicates that the size of copper nanoparticles decreases with the increase in concentration of L-ascorbic acid. L-Ascorbic acid plays an important role to protect the copper nanoparticles from oxidation and agglomeration which helps nanoparticles to get better stability for the application. The synthesized Cunps show excellent catalytic activity in the oxidation of serine（Ser） by peroxomonosulphate（PMS）. The catalytic activity of Cunps increases with the decrease in size of Cunps. The Cunps are expected to be suitable alternative and play an imperative role in the fields of catalysis and environmental remediation.展开更多
文摘Studies reporting the Indian prevalence of Epidermal Growth Factor Receptor (EGFR) mutation are mostly single centers with small sample sizes. This systematic review and meta-analysis summarized the available evidence of EGFR mutation epidemiology in Indian patients with adenocarcinoma (ADC) Non-Small Cell Lung Cancer (NSCLC). We conducted a structured literature search in PubMed, and EMBASE databases from January 2004 through October 2019. The primary outcome of interest was prevalence of EGFR mutation by gender, smoking status, and mutation subtype. The review included 34 studies. EGFR mutation prevalence was 39.5% in patients with ADC, and significantly higher in females, non-smokers, and patients with exon 19 deletions. The EGFR mutation frequency in Indian patients with ADC was higher than reported in Caucasians but at a lower range of that reported in East Asians. These findings support the use of EGFR mutation testing to guide choice of treatment.
文摘The synthesis and catalytic properties of copper nanoparticles（Cunps） were reported using L-ascorbic acid as reducing and capping agent in aqueous medium. The effect of different concentrations of L-ascorbic acid on the particle size of Cunps was investigated. The synthesized Cunps were characterized by UV-Visible spectrophotometer, scanning electron microscopy（SEM）, transmission electron microscopy（TEM） and Fourier transform infrared（FTIR） spectrophotometer. The result indicates that the size of copper nanoparticles decreases with the increase in concentration of L-ascorbic acid. L-Ascorbic acid plays an important role to protect the copper nanoparticles from oxidation and agglomeration which helps nanoparticles to get better stability for the application. The synthesized Cunps show excellent catalytic activity in the oxidation of serine（Ser） by peroxomonosulphate（PMS）. The catalytic activity of Cunps increases with the decrease in size of Cunps. The Cunps are expected to be suitable alternative and play an imperative role in the fields of catalysis and environmental remediation.
