AIM: To determine the prevalence of steatosis and steatohepatitis in a series of autopsies in Northwestern Greece. METHODS: Liver biopsy material from a total of 600 autopsies performed over a period of 2 years (2006-...AIM: To determine the prevalence of steatosis and steatohepatitis in a series of autopsies in Northwestern Greece. METHODS: Liver biopsy material from a total of 600 autopsies performed over a period of 2 years (2006-2008) to def ine the cause of death was subjected to histological examination. Patient demographic data were also collected. Tissue sections were stained with different dyes for the evaluation of liver architecture, degree of fibrosis and other pathological conditions when necessary. RESULTS: Satisfactory tissue samples for histological evaluation were available in 498 cases (341 male, 157 female) with a mean age of 64.51 ± 17.78 years. In total, 144 (28.9%) had normal liver histology, 156 (31.3%) had evidence of steatosis, and 198 (39.8%) had typical histological findings of steatohepatitis. The most common causes of death were ischemic heart disease with or without myocardial infarction (43.4%), and traffic accidents (13.4%). CONCLUSION: A high prevalence of steatosis and steatohepatitis was detected in postmortem biopsies from Northwestern Greece. Since both diseases can have serious clinical consequences, they should be considered as an important threat to the health of the general population in Greece.展开更多
The standard treatment of glioblastoma,the most common type of primary-brain-tumor,involves radiotherapy with concomitant temozolomide chemotherapy.A patient with glioblastoma,post radiotherapy developed magnatic reso...The standard treatment of glioblastoma,the most common type of primary-brain-tumor,involves radiotherapy with concomitant temozolomide chemotherapy.A patient with glioblastoma,post radiotherapy developed magnatic resonance imaging(MRI)changes consistent with either radiation-induced tumor necrosis or tumor recurrence.Perfusion MRI was suggestive of radiation necrosis,but magnetic resonance spectroscopy and 99mTc-Tetrofosmin single photon emission computed tomography was indicative of tumor recurrence.Positron emission tomography scan was not available.Tumor recurrence was documented by biopsy.Several advanced imaging methods are available to differentiate tumor recurrence from radiation necrosis in glioblastoma patients.However,in inconclusive cases,brain biopsy should be performed for definite diagnosis.展开更多
文摘AIM: To determine the prevalence of steatosis and steatohepatitis in a series of autopsies in Northwestern Greece. METHODS: Liver biopsy material from a total of 600 autopsies performed over a period of 2 years (2006-2008) to def ine the cause of death was subjected to histological examination. Patient demographic data were also collected. Tissue sections were stained with different dyes for the evaluation of liver architecture, degree of fibrosis and other pathological conditions when necessary. RESULTS: Satisfactory tissue samples for histological evaluation were available in 498 cases (341 male, 157 female) with a mean age of 64.51 ± 17.78 years. In total, 144 (28.9%) had normal liver histology, 156 (31.3%) had evidence of steatosis, and 198 (39.8%) had typical histological findings of steatohepatitis. The most common causes of death were ischemic heart disease with or without myocardial infarction (43.4%), and traffic accidents (13.4%). CONCLUSION: A high prevalence of steatosis and steatohepatitis was detected in postmortem biopsies from Northwestern Greece. Since both diseases can have serious clinical consequences, they should be considered as an important threat to the health of the general population in Greece.
文摘The standard treatment of glioblastoma,the most common type of primary-brain-tumor,involves radiotherapy with concomitant temozolomide chemotherapy.A patient with glioblastoma,post radiotherapy developed magnatic resonance imaging(MRI)changes consistent with either radiation-induced tumor necrosis or tumor recurrence.Perfusion MRI was suggestive of radiation necrosis,but magnetic resonance spectroscopy and 99mTc-Tetrofosmin single photon emission computed tomography was indicative of tumor recurrence.Positron emission tomography scan was not available.Tumor recurrence was documented by biopsy.Several advanced imaging methods are available to differentiate tumor recurrence from radiation necrosis in glioblastoma patients.However,in inconclusive cases,brain biopsy should be performed for definite diagnosis.
