A cheap method allowing fabrication of biocompatible,ultra-small(2-10 nm)and fluorescent(λ_(em)=425-500 nm)nanohybrids(NHs)from coffee wastes is reported.The gadolinium-doped nanohybrids(GDNHs)or gadolinium-free carb...A cheap method allowing fabrication of biocompatible,ultra-small(2-10 nm)and fluorescent(λ_(em)=425-500 nm)nanohybrids(NHs)from coffee wastes is reported.The gadolinium-doped nanohybrids(GDNHs)or gadolinium-free carbon dots(GFCDs)can be synthesized in a domestic microwave oven according to green synthesis principles.Hydrodynamic sizes,chemical composition,impact on proton magnetic resonance relaxation time and optical properties of the GDNHs and GFCDs were studied in details and compared.In particular,doping of the NHs with Gd^(3+)ions,up to 1.87%w/w of gadolinium per particles’weight,will allow their application for magnetic resonance imaging(MRI).Furthermore,cell culture tests on human adenocarcinomic alveolar basal epithelial cells line(A549)have shown high biocompatibility of the GDNHs and in a wide concentration range 100-1000μg/ml.展开更多
基金the support of EU Horizon 2020 Research and Innovation Staff Exchange Programme(RISE)under Marie Skłodowska-Curie Action(project 101008159“UNAT”).
文摘A cheap method allowing fabrication of biocompatible,ultra-small(2-10 nm)and fluorescent(λ_(em)=425-500 nm)nanohybrids(NHs)from coffee wastes is reported.The gadolinium-doped nanohybrids(GDNHs)or gadolinium-free carbon dots(GFCDs)can be synthesized in a domestic microwave oven according to green synthesis principles.Hydrodynamic sizes,chemical composition,impact on proton magnetic resonance relaxation time and optical properties of the GDNHs and GFCDs were studied in details and compared.In particular,doping of the NHs with Gd^(3+)ions,up to 1.87%w/w of gadolinium per particles’weight,will allow their application for magnetic resonance imaging(MRI).Furthermore,cell culture tests on human adenocarcinomic alveolar basal epithelial cells line(A549)have shown high biocompatibility of the GDNHs and in a wide concentration range 100-1000μg/ml.
