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Recent Advances in ^(19)Fluorine Magnetic Resonance Imaging with Perfluorocarbon Emulsions 被引量:2
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作者 anne h.schmieder Shelton D.Caruthers +2 位作者 Jochen Keupp Samuel A.Wickline Gregory M.Lanza 《Engineering》 SCIE EI 2015年第4期475-489,共15页
The research roots of 19fluorine (19F) magnetic resonance imaging (MRI) date back over 35 years. Over that time span, 1H imaging flourished and was adopted worldwide with an endless array of applications and imagi... The research roots of 19fluorine (19F) magnetic resonance imaging (MRI) date back over 35 years. Over that time span, 1H imaging flourished and was adopted worldwide with an endless array of applications and imaging approaches, making magnetic resonance an indispensable pillar of biomedical diagnostic imaging. For many years during this timeframe, 19F imaging research continued at a slow pace as the various attributes of the technique were explored. However, over the last decade and particularly the last several years, the pace and clinical relevance of 19F imaging has exploded. In part, this is due to advances in MRI instrumentation, ~gF/1H coil designs, and ultrafast pulse sequence development for both preclinical and clinical scanners. These achievements, coupled with interest in the molecular imaging of anatomy and physiology, and combined with a cadre of innovative agents, have brought the concept of ~gF into early clinical evaluation. In this review, we attempt to provide a slice of this rich history of research and development, with a particular focus on liquid perfluorocarbon compound-based agents. 展开更多
关键词 FLUORINE magnetic resonance imaging (MRI) dual-tuned coil PERFLUOROCARBON ANGIOGENESIS cell labeling
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