Objective Exercise is known to enhance circulating brain-derived neurotrophic factor （BDNF） levels in healthy humans. BDNF changes have been measured in endurance but not in strength exercise. The present study aime...Objective Exercise is known to enhance circulating brain-derived neurotrophic factor （BDNF） levels in healthy humans. BDNF changes have been measured in endurance but not in strength exercise. The present study aimed to investigate whether anaerobic activity such as sprinting differentially alters basal plasma BDNF concentration. Methods Brazilian sprinters （100 m） at either the international （Olympics and Outdoor World Championships） （n = 14） or the domestic level （n = 8）, and sedentary subjects （n = 15）, were recruited. Plasma BDNF concentrations were analyzed by enzyme-linked immunosorbent assay. Results The basal plasma BDNF concentrations were significantly higher in the international and the domestic sprinters than in the sedentary subjects. In addition, sprinters at the international level had higher plasma BDNF concentrations than those at the domestic level. Conclusion Our findings suggest that increased basal plasma BDNF level is related to enhanced exercise performance.展开更多
We read with interest the case report by Ban et al. about a 17-year-old male with myoclonic epilepsy with ragged red fibers （MERRF） syndrome being attributed to the mitochondrial tRNA glutamic acid （tRNA [Glu]） va...We read with interest the case report by Ban et al. about a 17-year-old male with myoclonic epilepsy with ragged red fibers （MERRF） syndrome being attributed to the mitochondrial tRNA glutamic acid （tRNA [Glu]） variant mitochondrial 14709T〉C. The authors claimed that the variant occurred sporadically and has not been reported in association with a MERRF phenotype so far. We have the following comments and concerns.展开更多
基金supported by Coordenao de Aperfeioamento de Pessoal de Nível Superior(CAPES)Fundao de Amparo à Pesquisa do Estado de So Paulo(FAPESP)+2 种基金Conselho Nacional de Desenvolvimento Científico e Tecnológico(CNPq)Instituto Nacional de Neurociência Translacional(INNT)Cooperao Interinstitucional de Apoio a Pesquisas sobre o Cérebro(CInAPCe),Brazil
文摘Objective Exercise is known to enhance circulating brain-derived neurotrophic factor （BDNF） levels in healthy humans. BDNF changes have been measured in endurance but not in strength exercise. The present study aimed to investigate whether anaerobic activity such as sprinting differentially alters basal plasma BDNF concentration. Methods Brazilian sprinters （100 m） at either the international （Olympics and Outdoor World Championships） （n = 14） or the domestic level （n = 8）, and sedentary subjects （n = 15）, were recruited. Plasma BDNF concentrations were analyzed by enzyme-linked immunosorbent assay. Results The basal plasma BDNF concentrations were significantly higher in the international and the domestic sprinters than in the sedentary subjects. In addition, sprinters at the international level had higher plasma BDNF concentrations than those at the domestic level. Conclusion Our findings suggest that increased basal plasma BDNF level is related to enhanced exercise performance.
文摘We read with interest the case report by Ban et al. about a 17-year-old male with myoclonic epilepsy with ragged red fibers （MERRF） syndrome being attributed to the mitochondrial tRNA glutamic acid （tRNA [Glu]） variant mitochondrial 14709T〉C. The authors claimed that the variant occurred sporadically and has not been reported in association with a MERRF phenotype so far. We have the following comments and concerns.
