Objective： To investigate the role of apparent diffusion coefficient （ADC） from diffusion-weighted magnetic resonance imaging （DW-MRI） when applied to the 7th TNM classification in the staging and prognosis of ga...Objective： To investigate the role of apparent diffusion coefficient （ADC） from diffusion-weighted magnetic resonance imaging （DW-MRI） when applied to the 7th TNM classification in the staging and prognosis of gastric cancer （GC）. Methods： Between October 2009 and May 2014, a total of 89 patients with non-metastatic, biopsy proven GC underwent 1.5T DW-MRI, and then treated with radical surgery. Tumor ADC was measured retrospectively and compared with final histology following the 7th TNM staging （local invasion, nodal involvement and according to the different groups -- stage Ⅰ, Ⅱ and Ⅲ）. Kaplan-Meier curves were also generated. The follow-up period is updated to May 2016. Results： Median follow-up period was 33 months and 45/89 （51%） deaths from GC were observed. ADC was significantly different both for local invasion and nodal involvement （P〈0.001）. Considering final histology as the reference standard, a preoperative ADC cut-offof 1.80×10-3 mm^2/s could distinguish between stages I and Ⅱ and an ADC value of ≤1.36-10-3 mm^2/s was associated with stage Ⅲ（P〈0.001）. Kaplan-Meier curves demonstrated that the survival rates for the three prognostic groups were significantly different according to final histology and ADC cut-offs （P〈0.001）. Conclusions： ADC is different according to local invasion, nodal involvement and the 7th TNM stage groups for GC, representing a potential, additional prognostic biomarker. The addition of DW-MRI could aid in the staging and risk stratification of GC.展开更多
The ability to measure the very high heat fluxes that typically occur during the hypersonic re-entry phase of space vehicles is generally considered a subject of great importance in the aerospace field.Most of the sen...The ability to measure the very high heat fluxes that typically occur during the hypersonic re-entry phase of space vehicles is generally considered a subject of great importance in the aerospace field.Most of the sensors used for these measurements need to be checked periodically and re-calibrated accordingly.Another bottleneck relates to the need to procure thermal sources that are able to generate reliable reference heat fluxes in the range between 100 and 1000 kW/m^(2)(as order of magnitude).In the present study,a method is presented by which,starting from a calibration system with a capacity of approximately 500 kW/m^(2) only,heat fluxes in the range of interest for hypersonic applications are generated.The related procedure takes advantage of established standards for the characterization of a radiative heat flux.It also builds on the hybrid radiative-convective nature of typical hypersonic heat fluxes and the yet poorly explored possibility to use convective sources of heat to produce high-intensity fluxes.The reliability of such a strategy has been tested using a high enthalpy supersonic flow facility relying on an electric arc-heater and pure Nitrogen as work gas.Stagnation-point heat fluxes have been successfully measured(with reasonable accuracy)in the range between 600 and 1500 kW/m^(2) for values of the centerline enthalpy spanning the interval from to 6 to 24 MJ/kg.展开更多
文摘Objective： To investigate the role of apparent diffusion coefficient （ADC） from diffusion-weighted magnetic resonance imaging （DW-MRI） when applied to the 7th TNM classification in the staging and prognosis of gastric cancer （GC）. Methods： Between October 2009 and May 2014, a total of 89 patients with non-metastatic, biopsy proven GC underwent 1.5T DW-MRI, and then treated with radical surgery. Tumor ADC was measured retrospectively and compared with final histology following the 7th TNM staging （local invasion, nodal involvement and according to the different groups -- stage Ⅰ, Ⅱ and Ⅲ）. Kaplan-Meier curves were also generated. The follow-up period is updated to May 2016. Results： Median follow-up period was 33 months and 45/89 （51%） deaths from GC were observed. ADC was significantly different both for local invasion and nodal involvement （P〈0.001）. Considering final histology as the reference standard, a preoperative ADC cut-offof 1.80×10-3 mm^2/s could distinguish between stages I and Ⅱ and an ADC value of ≤1.36-10-3 mm^2/s was associated with stage Ⅲ（P〈0.001）. Kaplan-Meier curves demonstrated that the survival rates for the three prognostic groups were significantly different according to final histology and ADC cut-offs （P〈0.001）. Conclusions： ADC is different according to local invasion, nodal involvement and the 7th TNM stage groups for GC, representing a potential, additional prognostic biomarker. The addition of DW-MRI could aid in the staging and risk stratification of GC.
文摘The ability to measure the very high heat fluxes that typically occur during the hypersonic re-entry phase of space vehicles is generally considered a subject of great importance in the aerospace field.Most of the sensors used for these measurements need to be checked periodically and re-calibrated accordingly.Another bottleneck relates to the need to procure thermal sources that are able to generate reliable reference heat fluxes in the range between 100 and 1000 kW/m^(2)(as order of magnitude).In the present study,a method is presented by which,starting from a calibration system with a capacity of approximately 500 kW/m^(2) only,heat fluxes in the range of interest for hypersonic applications are generated.The related procedure takes advantage of established standards for the characterization of a radiative heat flux.It also builds on the hybrid radiative-convective nature of typical hypersonic heat fluxes and the yet poorly explored possibility to use convective sources of heat to produce high-intensity fluxes.The reliability of such a strategy has been tested using a high enthalpy supersonic flow facility relying on an electric arc-heater and pure Nitrogen as work gas.Stagnation-point heat fluxes have been successfully measured(with reasonable accuracy)in the range between 600 and 1500 kW/m^(2) for values of the centerline enthalpy spanning the interval from to 6 to 24 MJ/kg.
