Dear Editor,One of the most serious issues in modern oncology is the ineffectiveness of treatments in destroying tumours,which leads to tumour recurrence and,ultimately,patient death.This phenomenon is caused by conve...Dear Editor,One of the most serious issues in modern oncology is the ineffectiveness of treatments in destroying tumours,which leads to tumour recurrence and,ultimately,patient death.This phenomenon is caused by conventional therapies’fractional killing of tumour cells,which can also cause resistant cells to spread.1 We analysed chemotherapy-resistant cells and discovered that they are smaller than untreated cells(Fig.1a).The fact that this phenomenon occurs in all tested cell types(Hela,A549,Huh7,and MCF7)and regardless of the chemotherapy regimen(TRAIL,Camptothecin,Doxorubicin)suggests that it is a widespread phenomenon(Fig.1a,Supplementary Fig.S1).展开更多
基金The Spanish Ministry of Science and Innovation supported this research grant reference:PID2019-111133RB-100F.J.I.acknowledges a grant from the European Sequencing and Genotyping Infrastructure(ESGI),Grant Agreement no.262055“Atracción de Talento”from the Comunidad de Madrid to PP(2016-T1/BMD-1051&2020-5 A/BMD-19731).Thanks to Dr.Rosa Farrás for lending us some antibodies.
文摘Dear Editor,One of the most serious issues in modern oncology is the ineffectiveness of treatments in destroying tumours,which leads to tumour recurrence and,ultimately,patient death.This phenomenon is caused by conventional therapies’fractional killing of tumour cells,which can also cause resistant cells to spread.1 We analysed chemotherapy-resistant cells and discovered that they are smaller than untreated cells(Fig.1a).The fact that this phenomenon occurs in all tested cell types(Hela,A549,Huh7,and MCF7)and regardless of the chemotherapy regimen(TRAIL,Camptothecin,Doxorubicin)suggests that it is a widespread phenomenon(Fig.1a,Supplementary Fig.S1).
