Herein,an electrochemically driven catalyst-free nucleophilic aromatic substitution(S_(N)Ar)of electron-rich fluoroarenes with carboxylic acids as weak nucleophiles under mild conditions was reported.A series of highl...Herein,an electrochemically driven catalyst-free nucleophilic aromatic substitution(S_(N)Ar)of electron-rich fluoroarenes with carboxylic acids as weak nucleophiles under mild conditions was reported.A series of highly valuable ester derivatives were obtained in a direct and rapid way.This transformation features commercially available reagents and an exceptionally broad substrate scope with good functional group tolerance,using cheap and abundant electrodes and completed within a short reaction time.Gram-scale synthesis and complex biorelevant compounds ligation further highlighted the potential utility of the methodology.The mechanistic investigations and density functional theory(DFT)calculations verified the feasibility of the proposed pathway of this transformation.展开更多
基金Financial support from National Key R&D Program of China(2022YFA1503200)National Natural Science Foundation of China(Grant No.22371149,22188101)+2 种基金the Fundamental Research Funds for the Central Universities(No.63223015)Frontiers Science Center for New Organic Matter,Nankai University(Grant No.63181206)Nankai University are gratefully acknowledged.
文摘Herein,an electrochemically driven catalyst-free nucleophilic aromatic substitution(S_(N)Ar)of electron-rich fluoroarenes with carboxylic acids as weak nucleophiles under mild conditions was reported.A series of highly valuable ester derivatives were obtained in a direct and rapid way.This transformation features commercially available reagents and an exceptionally broad substrate scope with good functional group tolerance,using cheap and abundant electrodes and completed within a short reaction time.Gram-scale synthesis and complex biorelevant compounds ligation further highlighted the potential utility of the methodology.The mechanistic investigations and density functional theory(DFT)calculations verified the feasibility of the proposed pathway of this transformation.
