Three-dimensional（3-D） coarse-grained Monte Carlo algorithms were used to simulate the conformations of swollen hydrogels formed by copper（I）-catalyzed azide-alkyne cycloaddition（Cu AAC）. The simulation consists...Three-dimensional（3-D） coarse-grained Monte Carlo algorithms were used to simulate the conformations of swollen hydrogels formed by copper（I）-catalyzed azide-alkyne cycloaddition（Cu AAC）. The simulation consists of three successive steps including diffusion, cross-linking and relaxation. The cross-linking of multifunctional reaction sites is simulated instantly followed by fast crosslinking. In order to explore the validity of this approach pristine poly（ethylene glycol）（PEG） hydrogels with tri- and tetra-functional reaction sites（G3 and G4 respectively） were prepared and characterized. The data from the simulations were found to be in good agreement with experimental results such as PEG lengths between crosslinks, pore volume and pore radius distribution, indicating the validity of the modeling algorithm. The calculated PEG lengths in G3 and G4 networks are close（≈ 4.6 nm）. The 3-D visual topological structure of the hydrogel network suggests that the ＂ideal＂ hydrogel is far from cubic, diamond or any well defined structures of regular repeating cells.展开更多
基金financially supported by the National Natural Science Foundation of China(Nos.21274020,21074022 and 21304019)Zhejiang Provincial Natural Science Foundation of China(No.Y4110115)
文摘Three-dimensional（3-D） coarse-grained Monte Carlo algorithms were used to simulate the conformations of swollen hydrogels formed by copper（I）-catalyzed azide-alkyne cycloaddition（Cu AAC）. The simulation consists of three successive steps including diffusion, cross-linking and relaxation. The cross-linking of multifunctional reaction sites is simulated instantly followed by fast crosslinking. In order to explore the validity of this approach pristine poly（ethylene glycol）（PEG） hydrogels with tri- and tetra-functional reaction sites（G3 and G4 respectively） were prepared and characterized. The data from the simulations were found to be in good agreement with experimental results such as PEG lengths between crosslinks, pore volume and pore radius distribution, indicating the validity of the modeling algorithm. The calculated PEG lengths in G3 and G4 networks are close（≈ 4.6 nm）. The 3-D visual topological structure of the hydrogel network suggests that the ＂ideal＂ hydrogel is far from cubic, diamond or any well defined structures of regular repeating cells.
