Sildenafil citrate is a potent and selective phosphodiesterase-5inhibitor. It is effectively used in the treatment of erectile dysfunction and pulmonary arterial hypertension. The drug is rapidly absorbed and pharmaco...Sildenafil citrate is a potent and selective phosphodiesterase-5inhibitor. It is effectively used in the treatment of erectile dysfunction and pulmonary arterial hypertension. The drug is rapidly absorbed and pharmacologically acts within30 min to 1 h after oral administration. However, it has a relatively low absolute bioavailability of 41%because its limited solubility in water is the major problem (1)To improve the oral bioavailability of poorly water-soluble drugs.展开更多
Sildenafil citrate is a highly selective phosphodiesterase-5(PDE-5)inhibitor.It is used for treatment of erectile dysfunction and pulmonary hypertension[1].Sildenafil citrate is categorized in BCS class 2 so it is dev...Sildenafil citrate is a highly selective phosphodiesterase-5(PDE-5)inhibitor.It is used for treatment of erectile dysfunction and pulmonary hypertension[1].Sildenafil citrate is categorized in BCS class 2 so it is developed as a citrate salt to increase water solubility(4.1 mg/mL)[2].The conventional product has been developed as a tablet dosage form.It is rapidly absorbed after oral administration,but gives a relatively low oral bioavailability of about 40%and late onset of action[2].Dry foam formulation technology is an alternative approach to overcome such a problem.展开更多
文摘Sildenafil citrate is a potent and selective phosphodiesterase-5inhibitor. It is effectively used in the treatment of erectile dysfunction and pulmonary arterial hypertension. The drug is rapidly absorbed and pharmacologically acts within30 min to 1 h after oral administration. However, it has a relatively low absolute bioavailability of 41%because its limited solubility in water is the major problem (1)To improve the oral bioavailability of poorly water-soluble drugs.
文摘Sildenafil citrate is a highly selective phosphodiesterase-5(PDE-5)inhibitor.It is used for treatment of erectile dysfunction and pulmonary hypertension[1].Sildenafil citrate is categorized in BCS class 2 so it is developed as a citrate salt to increase water solubility(4.1 mg/mL)[2].The conventional product has been developed as a tablet dosage form.It is rapidly absorbed after oral administration,but gives a relatively low oral bioavailability of about 40%and late onset of action[2].Dry foam formulation technology is an alternative approach to overcome such a problem.
