On-chip manipulation of charged particles using electrophoresis or electroosmosis is widely used for many applications,including optofluidic sensing,bioanalysis and macromolecular data storage.We hereby demonstrate a ...On-chip manipulation of charged particles using electrophoresis or electroosmosis is widely used for many applications,including optofluidic sensing,bioanalysis and macromolecular data storage.We hereby demonstrate a technique for the capture,localization,and release of charged particles and DNA molecules in an aqueous solution using tubular structures enabled by a strain-induced self-rolled-up nanomembrane(S-RuM)platform.Cuffed-in 3D electrodes that are embedded in cylindrical S-RuM structures and biased by a constant DC voltage are used to provide a uniform electrical field inside the microtubular devices.Efficient charged-particle manipulation is achieved at a bias voltage of<2-4 V,which is~3 orders of magnitude lower than the required potential in traditional DC electrophoretic devices.Furthermore,Poisson-Boltzmann multiphysics simulation validates the feasibility and advantage of our microtubular charge manipulation devices over planar and other 3D variations of microfluidic devices.This work lays the foundation for on-chip DNA manipulation for data storage applications.展开更多
基金This work was supported in part by the SemiSynBio grant:SRC 2018-SB-2839NSF CCF 18-07526。
文摘On-chip manipulation of charged particles using electrophoresis or electroosmosis is widely used for many applications,including optofluidic sensing,bioanalysis and macromolecular data storage.We hereby demonstrate a technique for the capture,localization,and release of charged particles and DNA molecules in an aqueous solution using tubular structures enabled by a strain-induced self-rolled-up nanomembrane(S-RuM)platform.Cuffed-in 3D electrodes that are embedded in cylindrical S-RuM structures and biased by a constant DC voltage are used to provide a uniform electrical field inside the microtubular devices.Efficient charged-particle manipulation is achieved at a bias voltage of<2-4 V,which is~3 orders of magnitude lower than the required potential in traditional DC electrophoretic devices.Furthermore,Poisson-Boltzmann multiphysics simulation validates the feasibility and advantage of our microtubular charge manipulation devices over planar and other 3D variations of microfluidic devices.This work lays the foundation for on-chip DNA manipulation for data storage applications.
