Purpose. To compare the longitudinal effects of treatment on intraocular pressure (IOP) and visual field performance in Japanese normal tension glaucoma (NTG) between latanoprost and timolol. Pati ents and methods. Th...Purpose. To compare the longitudinal effects of treatment on intraocular pressure (IOP) and visual field performance in Japanese normal tension glaucoma (NTG) between latanoprost and timolol. Pati ents and methods. This is an open label, randomized, study. A total of 62 NTG p atients were prospectively, consecutively enrolled. All study subjects were rand omly assigned to 0.005%latanoprost instillation once daily in the morning or 0. 5%timolol instillation twice daily for a prospective 3 year follow up, and un derwent a routine ocular examination every month. Automated perimetry was perfor med every 6 months using Humphrey field analysers. Stereophotographs of optic di scs were also obtained every 6 months. Results. Percentage of IOP reduction or t he magnitude of IOP reduction showed no intergroup differences either at any tim e point (13-15%). In the visual field, the estimated rate of change in the MD value (dB/year) was-0.34±0.17 (SE) for the latanoprost group, and-0.10±0.18 (SE) for the timolol group. The estimated rate of change in MD showed no signifi cant difference fromzero in both groups, and there were no statistical intergroup differences. No changes in the optic nerve head topography in the vertical cup to disc ratio and rim area measured by imageanalysis techniques were observed in either group. There were no patient s who dropped out due to the side effects of treatment regimens. Conclusion. Bot h latanoprost and timolol single treatments reduced IOP by 13-15%at their trou gh effects for 3 years in Japanese NTG patients; both showed similar effects on visual field performance.展开更多
Purpose. To evaluate the efficacy of topical autologous serum application to stop aqueous oozing or point-leak through filtering bleb after trabeculectomy. Patients and methods. A total of 21 consecutive eyes with ooz...Purpose. To evaluate the efficacy of topical autologous serum application to stop aqueous oozing or point-leak through filtering bleb after trabeculectomy. Patients and methods. A total of 21 consecutive eyes with oozing and 21 eyes with a point-leak through a functional bleb after trabeculectomy with 5- fluorouracil or mitomycin C were enrolled in this randomized, case-control study. In eyes randomly assigned to the serum group, an antibiotic and the autologous serum, which was sterilely diluted to 20% with physiological saline, were topically applied four times a day for up to 12 weeks. In eyes assigned to the control group, the antibiotic alone was applied according to the same protocol. Intraocular pressure (IOP) and the presence of oozing or a point-leak were tested before and every 2 weeks after starting the treatments. Results. In the serum and control groups, oozing stopped in 62.5 and 0% of eyes, respectively (P=0.003), and point-leaks stopped in 27.3 and 18.2% , respectively (P >0.9). IOP significantly increased from 10.0± 3.2 (mean± standard deviation) to 11.8± 3.3 mmHg in eyes in which oozing stopped (P=0.066), and from 11.4± 2.7 to 15.4± 2.3 mmHg in eyes in which a point-leak stopped (P=0.042). Conclusions. Autologous serum application was significantly effective to stop aqueous oozing but not point-leaks. Stopping oozing or point-leaks was significantly associated with an increase in IOP .展开更多
文摘Purpose. To compare the longitudinal effects of treatment on intraocular pressure (IOP) and visual field performance in Japanese normal tension glaucoma (NTG) between latanoprost and timolol. Pati ents and methods. This is an open label, randomized, study. A total of 62 NTG p atients were prospectively, consecutively enrolled. All study subjects were rand omly assigned to 0.005%latanoprost instillation once daily in the morning or 0. 5%timolol instillation twice daily for a prospective 3 year follow up, and un derwent a routine ocular examination every month. Automated perimetry was perfor med every 6 months using Humphrey field analysers. Stereophotographs of optic di scs were also obtained every 6 months. Results. Percentage of IOP reduction or t he magnitude of IOP reduction showed no intergroup differences either at any tim e point (13-15%). In the visual field, the estimated rate of change in the MD value (dB/year) was-0.34±0.17 (SE) for the latanoprost group, and-0.10±0.18 (SE) for the timolol group. The estimated rate of change in MD showed no signifi cant difference fromzero in both groups, and there were no statistical intergroup differences. No changes in the optic nerve head topography in the vertical cup to disc ratio and rim area measured by imageanalysis techniques were observed in either group. There were no patient s who dropped out due to the side effects of treatment regimens. Conclusion. Bot h latanoprost and timolol single treatments reduced IOP by 13-15%at their trou gh effects for 3 years in Japanese NTG patients; both showed similar effects on visual field performance.
文摘Purpose. To evaluate the efficacy of topical autologous serum application to stop aqueous oozing or point-leak through filtering bleb after trabeculectomy. Patients and methods. A total of 21 consecutive eyes with oozing and 21 eyes with a point-leak through a functional bleb after trabeculectomy with 5- fluorouracil or mitomycin C were enrolled in this randomized, case-control study. In eyes randomly assigned to the serum group, an antibiotic and the autologous serum, which was sterilely diluted to 20% with physiological saline, were topically applied four times a day for up to 12 weeks. In eyes assigned to the control group, the antibiotic alone was applied according to the same protocol. Intraocular pressure (IOP) and the presence of oozing or a point-leak were tested before and every 2 weeks after starting the treatments. Results. In the serum and control groups, oozing stopped in 62.5 and 0% of eyes, respectively (P=0.003), and point-leaks stopped in 27.3 and 18.2% , respectively (P >0.9). IOP significantly increased from 10.0± 3.2 (mean± standard deviation) to 11.8± 3.3 mmHg in eyes in which oozing stopped (P=0.066), and from 11.4± 2.7 to 15.4± 2.3 mmHg in eyes in which a point-leak stopped (P=0.042). Conclusions. Autologous serum application was significantly effective to stop aqueous oozing but not point-leaks. Stopping oozing or point-leaks was significantly associated with an increase in IOP .
