The various forms of non-melanocytic nevi (hamartomas) are usually encountered in pediatric patients, and nevus sebaceous of Jadassohn is the most common to have undifferentiated pilosebaceous units. We report a uniqu...The various forms of non-melanocytic nevi (hamartomas) are usually encountered in pediatric patients, and nevus sebaceous of Jadassohn is the most common to have undifferentiated pilosebaceous units. We report a unique congenital follicular nevus that fails to meet the criteria of any previously described follicular neoplasm, despite the plethora of alternatives. Clinically considered a syringocystadenoma papilliferum, the excised lesion contained multiple dermal nodules that exhibited nearly all stages of follicular differentiation. The periodicity of the follicular proliferations was akin to normal terminal hair, and a prominent perifollicular sheath surrounded each. This benign lesion of abortive hair follicles was unassociated with any established genodermatous syndrome or other adnexal neoplasm.展开更多
Our report describes a previously healthy 10- year-old female whow as seen for urticarial plaques andmild loss of appetite. An initial laboratory workup re vealed an elevated leukocyte count of 30,000/μ L and a perip...Our report describes a previously healthy 10- year-old female whow as seen for urticarial plaques andmild loss of appetite. An initial laboratory workup re vealed an elevated leukocyte count of 30,000/μ L and a peripheral eosinophil co unt of 22,500/μ L.A skin biopsy showed a marked hypersensitivity tissue respons e with abundant eosinophils. Further investigation of her peripheral eosinophili a uncovered Giardia lamblia in a stool sample. Despite treatment with the anti- parasitic agent furazolidone, the patient’s urticarial plaques, leukocyte cou nt, and peripheral eosinophil count remained unchanged. A bone marrow biopsy con firmed a diagnosis of acute lymphoblastic leukemia (ALL). ALL with hypereosinoph ilia (ALL/Eo) represents a rare and distinct subset of ALL, with more than 30 ca ses documented in the literature. Our discussion summarizes the clinical aspects of this disease and reviews the reported dermatological manifestations of ALL/E o.展开更多
文摘The various forms of non-melanocytic nevi (hamartomas) are usually encountered in pediatric patients, and nevus sebaceous of Jadassohn is the most common to have undifferentiated pilosebaceous units. We report a unique congenital follicular nevus that fails to meet the criteria of any previously described follicular neoplasm, despite the plethora of alternatives. Clinically considered a syringocystadenoma papilliferum, the excised lesion contained multiple dermal nodules that exhibited nearly all stages of follicular differentiation. The periodicity of the follicular proliferations was akin to normal terminal hair, and a prominent perifollicular sheath surrounded each. This benign lesion of abortive hair follicles was unassociated with any established genodermatous syndrome or other adnexal neoplasm.
文摘Our report describes a previously healthy 10- year-old female whow as seen for urticarial plaques andmild loss of appetite. An initial laboratory workup re vealed an elevated leukocyte count of 30,000/μ L and a peripheral eosinophil co unt of 22,500/μ L.A skin biopsy showed a marked hypersensitivity tissue respons e with abundant eosinophils. Further investigation of her peripheral eosinophili a uncovered Giardia lamblia in a stool sample. Despite treatment with the anti- parasitic agent furazolidone, the patient’s urticarial plaques, leukocyte cou nt, and peripheral eosinophil count remained unchanged. A bone marrow biopsy con firmed a diagnosis of acute lymphoblastic leukemia (ALL). ALL with hypereosinoph ilia (ALL/Eo) represents a rare and distinct subset of ALL, with more than 30 ca ses documented in the literature. Our discussion summarizes the clinical aspects of this disease and reviews the reported dermatological manifestations of ALL/E o.
