Dear Editor,Fungal keratitis is a serious and potentially sightthreatening infection that poses a global health concern,with higher incidence rates reported in low-income countries and regions with tropical climates[1...Dear Editor,Fungal keratitis is a serious and potentially sightthreatening infection that poses a global health concern,with higher incidence rates reported in low-income countries and regions with tropical climates[1-3].Risk factors for fungal keratitis include trauma with vegetative matter,contact lens wear,history of ocular surgery,chronic topical steroid use,low socioeconomic status and tropical climate[1-2].Fungi have the propensity to penetrate deep into the corneal stroma,making the infection difficult to treat with topical antifungal agents alone.Complications such as corneal perforation and endophthalmitis can arise in severe cases,making early identification of the causative fungal pathogen of utmost importance[4-5].Moreover,obtaining susceptibilities to the available antifungal agents can be sight and eye saving[5].展开更多
As a result of fundamental changes in the International Code of Nomenclature on the use of separate names for sexual and asexual stages of fungi,generic names of many groups should be reconsidered.Members of the ECMM/...As a result of fundamental changes in the International Code of Nomenclature on the use of separate names for sexual and asexual stages of fungi,generic names of many groups should be reconsidered.Members of the ECMM/ISHAM working group on Pseudallescheria/Scedosporium infections herein advocate a novel nomenclature for genera and species in Pseudallescheria,Scedosporium and allied taxa.The generic names Parascedosporium,Lomentospora,Petriella,Petriellopsis,and Scedosporium are proposed for a lineage within Microascaceae with mostly Scedosporium anamorphs producing slimy,annellidic conidia.Considering that Scedosporium has priority over Pseudallescheria and that Scedosporium prolificans is phylogenetically distinct from the other Scedosporium species,some name changes are proposed.Pseudallescheria minutispora and Petriellidium desertorum are renamed as Scedosporium minutisporum and S.desertorum,respectively.Scedosporium prolificans is renamed as Lomentospora prolificans.展开更多
Infectious agents,both standard and emerging or engineered,might initiate outbreaks with global impact and/or existential-level threat potential.Such agents might infect human,livestock,exploitable plant cultures or t...Infectious agents,both standard and emerging or engineered,might initiate outbreaks with global impact and/or existential-level threat potential.Such agents might infect human,livestock,exploitable plant cultures or the environment at large.Instead of responding by sampling teams which may also carry out prolonged surveillance,a more effective concept is to pre-process the samples,possibly to nucleic acid extract so as to transport them without biological risks by standard channels,or to process them up to a point and return the results,leaving the samples which only need specialized tests and dedicated equipment.In this context a portable device,allowing multiple routine and crisis-management applications due to its inherent flexibility,is scrutinized against alternatives and possible needs so as to develop a novel standard of surveillance and intervention,meant to facilitate containment by providing faster much more reliable laboratory results at a fraction of older generation mobile nucleic acids analyzers.Additional steps,such as agarose in pills and buffers pre-packaged in expendable syringes with pistons locked by improvised safety features may improve the Complexity Level of the whole system so as to make it appealing to intervention/crisis management personnel,while the instrument proper may double as backup for respective benchtop devices.展开更多
文摘Dear Editor,Fungal keratitis is a serious and potentially sightthreatening infection that poses a global health concern,with higher incidence rates reported in low-income countries and regions with tropical climates[1-3].Risk factors for fungal keratitis include trauma with vegetative matter,contact lens wear,history of ocular surgery,chronic topical steroid use,low socioeconomic status and tropical climate[1-2].Fungi have the propensity to penetrate deep into the corneal stroma,making the infection difficult to treat with topical antifungal agents alone.Complications such as corneal perforation and endophthalmitis can arise in severe cases,making early identification of the causative fungal pathogen of utmost importance[4-5].Moreover,obtaining susceptibilities to the available antifungal agents can be sight and eye saving[5].
文摘As a result of fundamental changes in the International Code of Nomenclature on the use of separate names for sexual and asexual stages of fungi,generic names of many groups should be reconsidered.Members of the ECMM/ISHAM working group on Pseudallescheria/Scedosporium infections herein advocate a novel nomenclature for genera and species in Pseudallescheria,Scedosporium and allied taxa.The generic names Parascedosporium,Lomentospora,Petriella,Petriellopsis,and Scedosporium are proposed for a lineage within Microascaceae with mostly Scedosporium anamorphs producing slimy,annellidic conidia.Considering that Scedosporium has priority over Pseudallescheria and that Scedosporium prolificans is phylogenetically distinct from the other Scedosporium species,some name changes are proposed.Pseudallescheria minutispora and Petriellidium desertorum are renamed as Scedosporium minutisporum and S.desertorum,respectively.Scedosporium prolificans is renamed as Lomentospora prolificans.
基金supported by the project“Synthetic Biology:From omics technologies to genomic engineering(OMIC-ENGINE)”(MIS:5002636)which is implemented under the Action“Reinforcement of the Research and Innovation Infrastructure”funded by the Operational Program"Competitiveness,Entrepreneurship and Innovation"(NSRF 2014-2020)co-financed by Greece and the European Union(European Regional Development Fund).
文摘Infectious agents,both standard and emerging or engineered,might initiate outbreaks with global impact and/or existential-level threat potential.Such agents might infect human,livestock,exploitable plant cultures or the environment at large.Instead of responding by sampling teams which may also carry out prolonged surveillance,a more effective concept is to pre-process the samples,possibly to nucleic acid extract so as to transport them without biological risks by standard channels,or to process them up to a point and return the results,leaving the samples which only need specialized tests and dedicated equipment.In this context a portable device,allowing multiple routine and crisis-management applications due to its inherent flexibility,is scrutinized against alternatives and possible needs so as to develop a novel standard of surveillance and intervention,meant to facilitate containment by providing faster much more reliable laboratory results at a fraction of older generation mobile nucleic acids analyzers.Additional steps,such as agarose in pills and buffers pre-packaged in expendable syringes with pistons locked by improvised safety features may improve the Complexity Level of the whole system so as to make it appealing to intervention/crisis management personnel,while the instrument proper may double as backup for respective benchtop devices.
