The membrane-anchored myelin enzyme 2′,3′-cyclic nucleotide 3′-phosphodiesterase（CNPase） was discovered in the early 1960 s and has since then troubled scientists with its peculiar catalytic activity and high exp...The membrane-anchored myelin enzyme 2′,3′-cyclic nucleotide 3′-phosphodiesterase（CNPase） was discovered in the early 1960 s and has since then troubled scientists with its peculiar catalytic activity and high expression levels in the central nervous system. Despite decades of research, the actual physiological relevance of CNPase has only recently begun to unravel. In addition to a role in myelination, CNPase is also involved in local adenosine production in traumatic brain injury and possibly has a regulatory function in mitochondrial membrane permeabilization. Although research focusing on the CNPase phosphodiesterase activity has been helpful, several open questions concerning the protein function in vivo remain unanswered. This review is focused on past research on CNPase, especially in the fields of structural biology and enzymology, and outlines the current understanding regarding the biochemical and physiological significance of CNPase, providing ideas and directions for future research.展开更多
基金supported by grants from the Department of Biochemistry,University of Ouluthe Sigrid Jusélius Foundation (Finland)+1 种基金the Academy of Finlandthe Hamburg Research and Science Foundation (Germany)
文摘The membrane-anchored myelin enzyme 2′,3′-cyclic nucleotide 3′-phosphodiesterase（CNPase） was discovered in the early 1960 s and has since then troubled scientists with its peculiar catalytic activity and high expression levels in the central nervous system. Despite decades of research, the actual physiological relevance of CNPase has only recently begun to unravel. In addition to a role in myelination, CNPase is also involved in local adenosine production in traumatic brain injury and possibly has a regulatory function in mitochondrial membrane permeabilization. Although research focusing on the CNPase phosphodiesterase activity has been helpful, several open questions concerning the protein function in vivo remain unanswered. This review is focused on past research on CNPase, especially in the fields of structural biology and enzymology, and outlines the current understanding regarding the biochemical and physiological significance of CNPase, providing ideas and directions for future research.
