Endoplasmic reticulum （ER） stress occurs upon the accumulation of unfolded or misfolded proteins, and induces adaptive mechanisms, termed the unfolded protein response （UPR）, aimed at resolving ER stress and hence...Endoplasmic reticulum （ER） stress occurs upon the accumulation of unfolded or misfolded proteins, and induces adaptive mechanisms, termed the unfolded protein response （UPR）, aimed at resolving ER stress and hence preventing potentially dysfunctional proteins from impairing proper cell fimction [1]. The UPR in general is an evolutionary highly conserved mechanism, with one branch in particular （the IRE 1-XBP 1 axis） conserved from yeast to metazoans including man.展开更多
Inflammatory Bowel Disease （IBD） is a dysregulated response of the im- mune system associated with intestinal tissues to the commensal microbiota in a genetically susceptible host. The understanding of the genetic b...Inflammatory Bowel Disease （IBD） is a dysregulated response of the im- mune system associated with intestinal tissues to the commensal microbiota in a genetically susceptible host. The understanding of the genetic basis of IBD has been significantly expanded with the advent of genome-wide association studies （GWAS） which has resulted in the identification of more than 30 loci that are associated with Crohn＇s disease （CD） and ulcerative colitis （UC）.展开更多
文摘Endoplasmic reticulum （ER） stress occurs upon the accumulation of unfolded or misfolded proteins, and induces adaptive mechanisms, termed the unfolded protein response （UPR）, aimed at resolving ER stress and hence preventing potentially dysfunctional proteins from impairing proper cell fimction [1]. The UPR in general is an evolutionary highly conserved mechanism, with one branch in particular （the IRE 1-XBP 1 axis） conserved from yeast to metazoans including man.
文摘Inflammatory Bowel Disease （IBD） is a dysregulated response of the im- mune system associated with intestinal tissues to the commensal microbiota in a genetically susceptible host. The understanding of the genetic basis of IBD has been significantly expanded with the advent of genome-wide association studies （GWAS） which has resulted in the identification of more than 30 loci that are associated with Crohn＇s disease （CD） and ulcerative colitis （UC）.
