Prospects to the formation and control of potential dimer impurity E of pantoprazole sodium sesquihydrate

Pantoprazole sodium, a substituted benzimidazole derivative, is an irreversible proton pump inhibitor which is primarily used for the treatment of duodenal ulcers, gastric ulcers, and gastroesophageal reflux disease (GERD). The monographs of European Pharmacopoeia (Ph. Eur.) and United States Pharmacopoeia (USP) specify six impurities, viz.;impurities A, B, C, D, E and F, respectively for its active pharmaceutical ingredient (API). The identification and synthesis of all impurities except impurity E are well described in the literature;however, there is no report related to impurity E. The prospects to the formation and controlling of impurity E up to -0.03% in the synthesis of pantoprazole sodium sesquihydrate (PAN) were discussed in detail for the first time. The present work described the journey towards the successful development of an optimal preparation procedure of dimer impurity E. The most plausible mechanism involved in the formation of impurity E has been proposed.

The energetic relationship among geoeffective solar flares, associated CMEs and SEPs

Major solar eruptions （flares, coronal mass ejections （CMEs） and solar energetic particles （SEPs）） strongly influence geospace and space weather. Currently, the mechanism of their influence on space weather is not well understood and requires a detailed study of the energetic relationship among these eruptive phenomena. From this perspective, we investigate 30 flares （observed by RHESSI）, followed by weak to strong geomagnetic storms. Spectral analysis of these flares suggests a new power-law relationship （r - 0.79） between the hard X-ray （HXR） spectral index （before flarepeak） and linear speed of the associated CME observed by LASCO/SOHO. For 12 flares which were followed by SEP enhancement near Earth, HXR and SEP spectral analysis reveals a new scaling law （r - 0.9） between the hardest X-ray flare spectrum and the hardest SEP spectrum. Furthermore, a strong correlation is obtained between the linear speed of the CME and the hardest spectrum of the corresponding SEP event （r - 0.96）. We propose that the potentially geoeffective flare and associated CME and SEP are well-connected through a possible feedback mechanism, and should be regarded within the framework of a solar eruption. Owing to their space weather effects, these new results will help improve our current understanding of the Sun-Earth relationship, which is a major goal of research programs in heliophysics.

Investigation of two coronal mass ejections from circular ribbon source region:Origin,Sun-Earth propagation and Geoeffectiveness

In this article,we compare the properties of two coronal mass ejections(CMEs)that show similar source region characteristics but different evolutionary behaviors in the later phases.We discuss the two events in terms of their near-Sun characteristics,interplanetary evolution and geoeffectiveness.We carefully analyzed the initiation and propagation parameters of these events to establish the precise CMEinterplanetary CME(ICME)connection and their near-Earth consequences.The first event is associated with poor geomagnetic storm disturbance index(Dst≈-20 n T)while the second event is associated with an intense geomagnetic storm of DST≈-119 n T.The configuration of the sunspots in the active regions and their evolution are observed by Helioseismic and Magnetic Imager(HMI).For source region imaging,we rely on data obtained from Atmospheric Imaging Assembly(AIA)on board Solar Dynamics Observatory(SDO)and Hαfiltergrams from the Solar Tower Telescope at Aryabhatta Research Institute of Observational Sciences(ARIES).For both the CMEs,flux rope eruptions from the source region triggered flares of similar intensities(≈M1).At the solar source region of the eruptions,we observed a circular ribbon flare(CRF)for both cases,suggesting fan-spine magnetic configuration in the active region corona.The multi-channel SDO observations confirm that the eruptive flares and subsequent CMEs were intimately related to the filament eruption.Within the Large Angle and Spectrometric Coronograph(LASCO)field of view(FOV)the two CMEs propagated with linear speeds of 671 and 631 km s-1,respectively.These CMEs were tracked up to the Earth by Solar Terrestrial Relations Observatory(STEREO)instruments.We find that the source region evolution of CMEs,guided by the large-scale coronal magnetic field configuration,along with near-Sun propagation characteristics,such as CME-CME interactions,played important roles in deciding the evolution of CMEs in the interplanetary medium and subsequently their geoeffectiveness.