Objective:To investigate demography,etiology,and clinical profile and to analyze the outcomes of patients presenting with febrile encephalopathy at a tertiary care center in Eastern India.Methods:This retrospective,ob...Objective:To investigate demography,etiology,and clinical profile and to analyze the outcomes of patients presenting with febrile encephalopathy at a tertiary care center in Eastern India.Methods:This retrospective,observational study included a total of 50 patients(>18 years)who presented with fever and encephalopathy.All patients underwent blood analysis;culture test for blood,urine,sputum,cerebrospinal fluid,and other body fluids;chest and abdominal ultrasonography;neuroimaging;polymerase chain reaction test,and other relevant tests as and when applicable.Results:The mean age of all enrolled patients was(58.0±16.0)years with male to female ratio of 1.27꞉1.Viral encephalitis was diagnosed in 16(32%)patients,sepsis-associated encephalitis in 14(28%),bacterial meningoencephalitis in 8(16%)and tuberculosis meningoencephalitis in 5(10%).The mean hospital stay was 10(4,17)days.At 6-month follow-up,10(20%)patients died,10(20%)patients recovered with sequelae(cognitive impairment,critical care neuropathy,etc.),and 30(60%)patients recovered without sequelae.A statistically significant association was noted between Glasgow Coma Scale(<8)and mortality rate(P=0.02).Conclusions:Primary central nervous system infection is the most frequent etiology of febrile encephalopathy and viral encephalitis is the most common etiological cause.Accurate,systematic,timely diagnosis and management are prime factors to reduce mortality and morbidity.展开更多
文摘Objective:To investigate demography,etiology,and clinical profile and to analyze the outcomes of patients presenting with febrile encephalopathy at a tertiary care center in Eastern India.Methods:This retrospective,observational study included a total of 50 patients(>18 years)who presented with fever and encephalopathy.All patients underwent blood analysis;culture test for blood,urine,sputum,cerebrospinal fluid,and other body fluids;chest and abdominal ultrasonography;neuroimaging;polymerase chain reaction test,and other relevant tests as and when applicable.Results:The mean age of all enrolled patients was(58.0±16.0)years with male to female ratio of 1.27꞉1.Viral encephalitis was diagnosed in 16(32%)patients,sepsis-associated encephalitis in 14(28%),bacterial meningoencephalitis in 8(16%)and tuberculosis meningoencephalitis in 5(10%).The mean hospital stay was 10(4,17)days.At 6-month follow-up,10(20%)patients died,10(20%)patients recovered with sequelae(cognitive impairment,critical care neuropathy,etc.),and 30(60%)patients recovered without sequelae.A statistically significant association was noted between Glasgow Coma Scale(<8)and mortality rate(P=0.02).Conclusions:Primary central nervous system infection is the most frequent etiology of febrile encephalopathy and viral encephalitis is the most common etiological cause.Accurate,systematic,timely diagnosis and management are prime factors to reduce mortality and morbidity.
