The non-specific beneficial effects of Bacille Calmette-Guérin(BCG)vaccination suggest that this vaccine might play a role in protecting individuals against severe coronavirus disease 2019(COVID-19).Several studi...The non-specific beneficial effects of Bacille Calmette-Guérin(BCG)vaccination suggest that this vaccine might play a role in protecting individuals against severe coronavirus disease 2019(COVID-19).Several studies propose that BCG vaccination may increase the body's immunity,thereby preventing respiratory infections caused by other respiratory pathogens.As the number of deaths due to COVID-19 is increasing rapidly and there is no specific treatment available to date,scientists are evaluating the effectiveness of already approved drugs as therapies against COVID-19,and the results were found to vary widely:from no significant effect being observed to a reduction in the time taken for clinical improvement.This study thus aims to evaluate whether it is worth performing clinical trials to examine the effects of the BCG vaccine on COVID-19.We herein emphasize the need to conduct phase III randomized controlled trials with adequate sample size and quality to investigate the effects of the BCG vaccine on COVID-19.In the event that BCG vaccination provides non-specific protection against COVID-19,administering it could be helpful in controlling the transmission of COVID-19 and other infectious diseases during future pandemics.展开更多
文摘The non-specific beneficial effects of Bacille Calmette-Guérin(BCG)vaccination suggest that this vaccine might play a role in protecting individuals against severe coronavirus disease 2019(COVID-19).Several studies propose that BCG vaccination may increase the body's immunity,thereby preventing respiratory infections caused by other respiratory pathogens.As the number of deaths due to COVID-19 is increasing rapidly and there is no specific treatment available to date,scientists are evaluating the effectiveness of already approved drugs as therapies against COVID-19,and the results were found to vary widely:from no significant effect being observed to a reduction in the time taken for clinical improvement.This study thus aims to evaluate whether it is worth performing clinical trials to examine the effects of the BCG vaccine on COVID-19.We herein emphasize the need to conduct phase III randomized controlled trials with adequate sample size and quality to investigate the effects of the BCG vaccine on COVID-19.In the event that BCG vaccination provides non-specific protection against COVID-19,administering it could be helpful in controlling the transmission of COVID-19 and other infectious diseases during future pandemics.
