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Positron emission tomography to assess hypoxia and perfusion in lung cancer 被引量:3
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作者 Eline E Verwer Ronald Boellaard astrid am van der veldt 《World Journal of Clinical Oncology》 CAS 2014年第5期824-844,共21页
In lung cancer, tumor hypoxia is a characteristic feature, which is associated with a poor prognosis and resistance to both radiation therapy and chemotherapy. As the development of tumor hypoxia is associated with de... In lung cancer, tumor hypoxia is a characteristic feature, which is associated with a poor prognosis and resistance to both radiation therapy and chemotherapy. As the development of tumor hypoxia is associated with decreased perfusion, perfusion measurements provide more insight into the relation between hypoxia and perfusion in malignant tumors. Positron emission tomography(PET) is a highly sensitive nuclear imaging technique that is suited for non-invasive in vivo monitoring of dynamic processes including hypoxia and its associated parameter perfusion. The PET technique enables quantitative assessment of hypoxia and perfusion in tumors. To this end, consecutive PET scans can be performed in one scan session. Using different hypoxia tracers, PET imaging may provide insight into the prognostic significance of hypoxia and perfusion in lung cancer. In addition, PET studies may play an important role in various stages of personalized medicine, as these may help to select patients for specifictreatments including radiation therapy, hypoxia modifying therapies, and antiangiogenic strategies. In addition, specific PET tracers can be applied for monitoring therapy. The present review provides an overview of the clinical applications of PET to measure hypoxia and perfusion in lung cancer. Available PET tracers and their characteristics as well as the applications of combined hypoxia and perfusion PET imaging are discussed. 展开更多
关键词 Molecular imaging POSITRON emission TOMOGRAPHY HYPOXIA PERFUSION Quantification LUNG cancer
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An unusual cause of hematemesis:Goiter
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作者 astrid am van der veldt Mohammed Hadithi +3 位作者 Marinus A Paul Fred G van den Berg Chris JJ Mul-der Mikael E Craanen 《World Journal of Gastroenterology》 SCIE CAS CSCD 2006年第33期5412-5415,共4页
Downhill varices are located in the upper part of the esophagus and are usually related to superior vena cava obstruction. Bleeding from these varices is extremely rare. We describe a 77-year-old patient with hemateme... Downhill varices are located in the upper part of the esophagus and are usually related to superior vena cava obstruction. Bleeding from these varices is extremely rare. We describe a 77-year-old patient with hematemesis due to downhill varices as a result of recurrent goiter. A right lobe thyroidectomy was carried out with disappearance of the varices. 展开更多
关键词 甲状腺肿 食管疾病 静脉曲张 病理机制
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