Effect of Cymbopogon citratus Stapf extract on lipid profile and antioxidant status in streptozotocin-induced diabetic rats

OBJECTIVE To investigate the effects of Cymbopogon citratus Stapf water extract on lipid profile and antioxidant status in streptozotocin-induced diabetic rats.METHODS Diabetes was induced by injection of streptozotocin(STZ,50mg·kg-1)intraperitoneally.Diabetic rats were divided into 5groups,consisting of 6rats.GroupⅠ,reserved as diabetic control,was administered distilled water and groupⅡ,reserved as positive control,was administered glibenclamide(10mg·kg-1·d-1)throughout the duration of the experiment.Those in groupⅢ,ⅣandⅤ were administered 250,500 and 1000mg·kg-1·d-1 of the extract,respectively for 28 d.RESULTS Treatment with 500 and 1000mg·kg-1·d-1 of the extract resulted in reduction of serum AST,ALT,serum cholesterol,triglycerides and LDL,whereas HDL was found to be increased compared with diabetic control rats(P<0.05).Moreover,increased serum activities of superoxide dismutases and catalase were found in diabetic rats treated with the extract whereas serum thiobarbituric acid reactive substance was decreased,in comparison with diabetic control rat(P<0.05).CONCLUSION Cymbopogon citratus Stapf water extract provides a benefit effect on serum lipid and antioxidant effect in diabetic rats.Thus,the extract may lower cardiovascular disease risk and others complications related to hyperlipidemia and oxidative stress in diabetic patients.

Improvement of lipid profile and atherogenic index in rat treated with Cymbopogon citratus Stapf water extract

OBJECTIVE To investigate the effects of Cymbopogon citratus Stapf water extract(CCS)on lipid profile,atherogenic index and antioxidant enzymes in Sprague-Dawley rats.METHODS Rats aged eight weeks(250±20)g were orally administered with CCS at 250 and 500mg·kg-1·d-1 for one month.RESULTS Administration of CCS extract to rats caused significant decrease of serum total cholesterol,triglycerides and LDL levels,whereas,the HDL level was increased compared with untreated rats(P<0.05).Moreover,the CCS extract showed a significant decreased atherogenic index in comparison with untreated rats(P<0.05).Furthermore,serum activities of superoxide dismutases and catalase were also improved in rats treated with CCS.This was consistent with decrease of serum thiobarbituric acid reactive substance.CONCLUSION The present study provides evidence that CCS water extract provides a benefit effect on serum lipid and atherogenic index and exhibits antioxidant effect in vivo.