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Effects of tomato juice on the pharmacokinetics of CYP3A4-substrate drugs 被引量:1
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作者 atsuko ohkubo Tomomi Chida +2 位作者 Hidetomo Kikuchi Tadashi Tsuda Katsuyoshi Sunaga 《Asian Journal of Pharmaceutical Sciences》 SCIE CAS 2017年第5期464-469,共6页
We previously demonstrated that tomato juice(TJ) contains potent mechanism-based inhibitor(s) of CYP3A4. In this study, we investigated the effects of TJ and grapefruit juice(GFJ)on the pharmacokinetics of the CYP3A4-... We previously demonstrated that tomato juice(TJ) contains potent mechanism-based inhibitor(s) of CYP3A4. In this study, we investigated the effects of TJ and grapefruit juice(GFJ)on the pharmacokinetics of the CYP3A4-substrate drugs, nifedipine(NFP) and midazolam(MDZ), in male Wistar rats. Oral administration of GFJ 90 min before the intraduodenal administration of NFP or MDZ increased the area under the concentration–time curves(AUCs)of NFP and MDZ by 32.4% and 89.4%, respectively. TJ increased MDZ blood concentrations and AUC after intraduodenal MDZ administration;however, it had no effect on NFP. When MDZ and NFP were intravenously administered, GFJ significantly increased the AUC of MDZ,but only slightly increased that of NFP. In contrast, TJ only slightly increased the AUC of MDZ.These results suggest that, similar to GFJ, TJ influences the pharmacokinetics of CYP3A4-substrate drugs;however, it may be a drug-dependent partial effect. 展开更多
关键词 Food–drug INTERACTIONS Tomato JUICE GRAPEFRUIT JUICE NIFEDIPINE MIDAZOLAM PHARMACOKINETIC INTERACTIONS
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