We investigated whether brain SPECT findings show any differences between pat ients with mild and moderate Alzheimer’ s disease (AD) and to compare results w ith event related potentials (ERPs). Twenty- two patients ...We investigated whether brain SPECT findings show any differences between pat ients with mild and moderate Alzheimer’ s disease (AD) and to compare results w ith event related potentials (ERPs). Twenty- two patients with mild to moderate AD diagnosed according to NINCDS- ADRDA criteria and 10 age- matched control subjects were included in this prospective study. All subjects underwent ERP rec ordings and Tc- 99m HMPAO brain SPECT study. Cortical perfusion index (CPI)- w as calculated as the ratio of cortical activity to the cerebellum activity. CPI was found to be statistically lower in bilaterally posterolateral temporal corte x and precuneus in the moderate AD compared to the control group. There was no s tatistically significant difference between the mild AD and control groups for C PI in any cortical areas. The mean P300 latency was statistically prolonged in t he mild and moderate AD compared to the control group. In addition, in moderate AD P300 latency was longer than in mild AD. While the mean P300 amplitude was st atistically reduced in moderate AD compared to the control and mild AD, there wa s no statistically significant difference between the mild AD and control groups . There was a strong negative correlation between P300 latency and CPI in the ri ght and left precuneus in the moderate AD group. The present study suggested tha t Tc- 99m HMPAO SPECT study is the more appropriate technique for patients with moderate AD rather than mild AD. Our results indicated that alterations in ERPs , especially prolongation of P300 latency could be a finding that occurred earli er than the deterioration in cerebral blood flow. We thought that precuneus is c losely related to cognitive function and may have an important role in the patho physiology of AD.展开更多
Background: Narrow band ultraviolet B (NB-UVB) phototherapy has been used successfully for the treatment of vitiligo. Recently, topical calcipotriol has also been claimed to be effective, either as monotherapy or as a...Background: Narrow band ultraviolet B (NB-UVB) phototherapy has been used successfully for the treatment of vitiligo. Recently, topical calcipotriol has also been claimed to be effective, either as monotherapy or as a part of combination therapies. Objective: The aimof the present studywas to compare the clinical efficacy of NB-UVB and NB-UVB plus topical calcipotriol in the treatment of vitiligo. Methods: NB-UVB treatment was given to 24 patientswith generalized vitiligo three times weekly. Topical calcipotriol cream was only applied to the lesions located on the right side of the body. Treatment was continued for 6 months. Treatment efficacy was evaluated by determining the average response rates of the lesions at 3-month intervals. Result: The average response rates of patients receiving combination of NB-UVB plus calcipotriol and NB-UVB alone were 51 ± 19.6% and 39 ± 18.9% , respectively. The median cumulative UVB dose and number of UVB exposures for initial repigmentation were 6345 mj/cm2 (range; 2930- 30980) and 18 (range; 12- 67) for the combination therapy, and 8867.5 mj/cm2 (range; 2500- 30980) and 24 (range; 15- 67) for the narrow band UVB therapy, respectively. Conclusions: These findings indicate that concurrent topical calcipotriol potentates the efficacy of NB-UVB in the treatment of vitiligo. This combination not only provides earlier pigmentation with lower total UVB dosage and less adverse UVB effects, but also reduces the duration and cost of treatment as well.展开更多
Neutrophilic dermatosis of the dorsal hands is a recently described disorder, which is similar to Sweet’s syndrome. It is characterized by erythematous plaques, pustules and haemorrhagic bullae located solely on the ...Neutrophilic dermatosis of the dorsal hands is a recently described disorder, which is similar to Sweet’s syndrome. It is characterized by erythematous plaques, pustules and haemorrhagic bullae located solely on the dorsal surface of the hands. We describe a 57-year-old man with neutrophilic dermatosis of the dorsal hands that occurred following exposure to a chemical fertilizer. There are few cases reported in the literature regarding neutrophilic dermatosis and the aetiology remains unclear. For the present case, we propose that neutrophilic dermatosis of the dorsal hands might have been induced by the chemical fertilizer.展开更多
文摘We investigated whether brain SPECT findings show any differences between pat ients with mild and moderate Alzheimer’ s disease (AD) and to compare results w ith event related potentials (ERPs). Twenty- two patients with mild to moderate AD diagnosed according to NINCDS- ADRDA criteria and 10 age- matched control subjects were included in this prospective study. All subjects underwent ERP rec ordings and Tc- 99m HMPAO brain SPECT study. Cortical perfusion index (CPI)- w as calculated as the ratio of cortical activity to the cerebellum activity. CPI was found to be statistically lower in bilaterally posterolateral temporal corte x and precuneus in the moderate AD compared to the control group. There was no s tatistically significant difference between the mild AD and control groups for C PI in any cortical areas. The mean P300 latency was statistically prolonged in t he mild and moderate AD compared to the control group. In addition, in moderate AD P300 latency was longer than in mild AD. While the mean P300 amplitude was st atistically reduced in moderate AD compared to the control and mild AD, there wa s no statistically significant difference between the mild AD and control groups . There was a strong negative correlation between P300 latency and CPI in the ri ght and left precuneus in the moderate AD group. The present study suggested tha t Tc- 99m HMPAO SPECT study is the more appropriate technique for patients with moderate AD rather than mild AD. Our results indicated that alterations in ERPs , especially prolongation of P300 latency could be a finding that occurred earli er than the deterioration in cerebral blood flow. We thought that precuneus is c losely related to cognitive function and may have an important role in the patho physiology of AD.
文摘Background: Narrow band ultraviolet B (NB-UVB) phototherapy has been used successfully for the treatment of vitiligo. Recently, topical calcipotriol has also been claimed to be effective, either as monotherapy or as a part of combination therapies. Objective: The aimof the present studywas to compare the clinical efficacy of NB-UVB and NB-UVB plus topical calcipotriol in the treatment of vitiligo. Methods: NB-UVB treatment was given to 24 patientswith generalized vitiligo three times weekly. Topical calcipotriol cream was only applied to the lesions located on the right side of the body. Treatment was continued for 6 months. Treatment efficacy was evaluated by determining the average response rates of the lesions at 3-month intervals. Result: The average response rates of patients receiving combination of NB-UVB plus calcipotriol and NB-UVB alone were 51 ± 19.6% and 39 ± 18.9% , respectively. The median cumulative UVB dose and number of UVB exposures for initial repigmentation were 6345 mj/cm2 (range; 2930- 30980) and 18 (range; 12- 67) for the combination therapy, and 8867.5 mj/cm2 (range; 2500- 30980) and 24 (range; 15- 67) for the narrow band UVB therapy, respectively. Conclusions: These findings indicate that concurrent topical calcipotriol potentates the efficacy of NB-UVB in the treatment of vitiligo. This combination not only provides earlier pigmentation with lower total UVB dosage and less adverse UVB effects, but also reduces the duration and cost of treatment as well.
文摘Neutrophilic dermatosis of the dorsal hands is a recently described disorder, which is similar to Sweet’s syndrome. It is characterized by erythematous plaques, pustules and haemorrhagic bullae located solely on the dorsal surface of the hands. We describe a 57-year-old man with neutrophilic dermatosis of the dorsal hands that occurred following exposure to a chemical fertilizer. There are few cases reported in the literature regarding neutrophilic dermatosis and the aetiology remains unclear. For the present case, we propose that neutrophilic dermatosis of the dorsal hands might have been induced by the chemical fertilizer.
