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1例恶性萎缩性丘疹患者出现阴茎痛性溃疡
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作者 aydogan k. Alkan G. +1 位作者 karadogan koran S. 吴佳纹 《世界核心医学期刊文摘(皮肤病学分册)》 2006年第3期16-17,共2页
Malignant atrophic papulosis (MAP) is a rare, obliterating vasculopathy affecting multiple systems, frequently with a poor prognosis. Although cutaneous lesions are often the initial presentation, systemic involvement... Malignant atrophic papulosis (MAP) is a rare, obliterating vasculopathy affecting multiple systems, frequently with a poor prognosis. Although cutaneous lesions are often the initial presentation, systemic involvement is also common, usually with a fatal outcome. Involvement of the genitalia is very rare. We describe a 45-year-old male patient with multisytemic manifestation of MAP accompanied by painful penile ulceration. The pathogenesis of MAP is not yet fully understood and effective treatment choices are limited. In our case, the combination of pentoxifylline and dipyridamole failed to provide a beneficial effect on the progression of the disease and the patient died due to intestinal and intrathoracic manifestation of MAP. In the present case, attention should be drawn to the following clinical course and therapeutic properties: (i) we describe the second patient in the literature diagnosed with MAPand painful penile ulceration; (ii) to our knowledge, this is the first reported case with oesophageal fistula due to MAP; (iii) we could not confirm the efficacy of pentoxifylline, the recently reported treatment modality, in our patient. 展开更多
关键词 恶性萎缩性丘疹病 男性患者 溃疡 痛性 阴茎 多系统病变 出现 血管病变 己酮可可碱 MAP
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土耳其慢性寻常型荨麻疹患者的HLAI类抗原与II类抗原
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作者 aydogan k. karadogan S.k. +2 位作者 Akdag I. Tunali S. 潘敏 《世界核心医学期刊文摘(皮肤病学分册)》 2006年第6期46-46,共1页
Background. Chronic urticaria is a common disease with an unclear pathogenesis, which may be resistant to therapy. Recent studies have focused primarily on a possible autoimmune basis. Aim. To investigate HLA class I ... Background. Chronic urticaria is a common disease with an unclear pathogenesis, which may be resistant to therapy. Recent studies have focused primarily on a possible autoimmune basis. Aim. To investigate HLA class I and II antigens in a Turkish population with chronic ordinary urticaria (COU; not physical, vasculitic or contact), and identify susceptible HLA antigens. Methods. HLA antigens were investigated in 55 patients diagnosed with COU, using a two-stage microdroplet lymphocytotoxicity test, with 104 healthy and genetically unrelated individuals evaluated as the control group. Results. HLA Bw4 and HLA DQ1 antigens were significantly higher in the study group (odds ratio (OR) = 2.93, 95%CI 1.47-5.85, P =0.003 and OR = 7.81, 95%CI 1.96-28.50, P = 0.001, respectively)whereas HLA-A24 antigen was higher in controls (OR= 0.36, 95%CI 0.15-0.86, P = 0.03). Conclusion. We propose that HLA-Bw4 and DQ1 antigens may be responsible for susceptibility to COU while HLA-A24 may have a protective role in the Turkish population. 展开更多
关键词 HLAⅠ类抗原 慢性荨麻疹 Ⅱ类抗原 土耳其 寻常型 患者 HLA抗原 淋巴细胞毒性 遗传相关性 对照组
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红斑狼疮伴发多形红斑:2例病例报道及文献综述
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作者 aydogan k. karadogan S.k. +2 位作者 Balaban Adim S. Tunali S. 吴佳纹 《世界核心医学期刊文摘(皮肤病学分册)》 2006年第3期17-17,共1页
Rowell s syndrome (RS) is a rare presentation of lupus erythe- matosus (LE) with erythema multiforme-like lesions associated with antinuclear, anti-La (SS-B)/anti-Ro (SS-A) antibodies and rheumatoid factor (RF) posi... Rowell s syndrome (RS) is a rare presentation of lupus erythe- matosus (LE) with erythema multiforme-like lesions associated with antinuclear, anti-La (SS-B)/anti-Ro (SS-A) antibodies and rheumatoid factor (RF) positivity. This syndrome is suggested to be a different variant of cutaneous lupus erythematosus by some authors in literature. Here we present a 64-year-old woman with LE and a 51-year-old woman with LE and Sj¨ ogren syndrome (SS) who had erythema multiforme-like eruptions and discuss the coexistence of lupus erythematosus and erythema multiforme. 展开更多
关键词 皮肤红斑狼疮 多形红斑 文献综述 SJOGREN综合征 病例报道 伴发 类风湿因子(RF) 抗核抗体 红斑样 51岁
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低补体血症荨麻疹性血管炎:一种系统性红斑狼疮的罕见症状
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作者 aydogan k. karadogan S.k. +2 位作者 Adim S.B. Tunali S. 周炳荣 《世界核心医学期刊文摘(皮肤病学分册)》 2006年第12期25-25,共1页
Background: Urticarial vasculitis is a small-vessel vasculitis, presenting clinically as persistent urticarial skin lesions and microscopically as leucocytoclastic vasculitis. Hypocomplementemic urticarial vasculitis ... Background: Urticarial vasculitis is a small-vessel vasculitis, presenting clinically as persistent urticarial skin lesions and microscopically as leucocytoclastic vasculitis. Hypocomplementemic urticarial vasculitis syndrome (HUVS) is a distinct type of urticarial vasculitis with multiorgan involvement,whose etiology and link with other diseases are still unknown. Some authors have suggested that HUVS can be accompanied by systemic lupus erythematosus (SLE), and others believe that it is a rare subtype of SLE. Urticarial vasculitis is seen in 7-8%of SLE, while 50%of HUVS patients are diagnosed with SLE. Observations and results: We report a case of HUVS associated with SLE with fatal outcome unresponsive to the combination of systemic corticosteroids and azathioprine. Conclusions: SLE and HUVS share both clinical and laboratory features and are probably not separate entities. It is mostly likely that HUVS and SLE fall into the same spectrum of autoimmune diseases. HUVS is probably a subset of SLE.As both diseases can fatally, it should be kept in mind that the overlap of SLE and HUVS may exhibit a relatively rapid progression and poor prognosis. 展开更多
关键词 荨麻疹性血管炎 系统性红斑狼疮 低补体血症
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