Peroxisome proliferator-activated receptors(PPARs)are a superfamily of nuclear transcription receptors,consisting of PPARa,PPARy,and PPARβ/δ,which are highly expressed in the liver.They control and modulate the expr...Peroxisome proliferator-activated receptors(PPARs)are a superfamily of nuclear transcription receptors,consisting of PPARa,PPARy,and PPARβ/δ,which are highly expressed in the liver.They control and modulate the expression of a large number of genes involved in metabolism and energy homeostasis,oxidative stress,inflammation,and even apo-ptosis in the liver.Therefore,they have critical roles in the pathophysiology of hepatic diseases.This review provides a general insight into the role of PPARS in liver diseases and some of their agonists in the clinic.展开更多
Sterol regulator element binding proteins(SREBPs)are a family of transcription factors involved in the biogenesis of cholesterol,fatty acids and triglycerides.They also regulate physiological functions of many organs,...Sterol regulator element binding proteins(SREBPs)are a family of transcription factors involved in the biogenesis of cholesterol,fatty acids and triglycerides.They also regulate physiological functions of many organs,such as thyroid,brain,heart,pancreas and hormone synthesis.Beside the physiological effects,SREBPs participate in some pathological processes,diabetes,endoplasmic reticulum stress,atherosclerosis and chronic kidney disease associated with SREBP expression changes.In the liver,SREBPs are involved in the pathogenesis of nonalcoholic fatty liver disease,nonalcoholic steatohepatitis,hepatitis and hepatic cancer.There are several SREBP inhibitors that have potential for treating obesity,diabetes and cancer.This review assesses the recent findings about the roles of SREBPs in the physiology of organs'function and pathogenesis of liver diseases.展开更多
文摘Peroxisome proliferator-activated receptors(PPARs)are a superfamily of nuclear transcription receptors,consisting of PPARa,PPARy,and PPARβ/δ,which are highly expressed in the liver.They control and modulate the expression of a large number of genes involved in metabolism and energy homeostasis,oxidative stress,inflammation,and even apo-ptosis in the liver.Therefore,they have critical roles in the pathophysiology of hepatic diseases.This review provides a general insight into the role of PPARS in liver diseases and some of their agonists in the clinic.
文摘Sterol regulator element binding proteins(SREBPs)are a family of transcription factors involved in the biogenesis of cholesterol,fatty acids and triglycerides.They also regulate physiological functions of many organs,such as thyroid,brain,heart,pancreas and hormone synthesis.Beside the physiological effects,SREBPs participate in some pathological processes,diabetes,endoplasmic reticulum stress,atherosclerosis and chronic kidney disease associated with SREBP expression changes.In the liver,SREBPs are involved in the pathogenesis of nonalcoholic fatty liver disease,nonalcoholic steatohepatitis,hepatitis and hepatic cancer.There are several SREBP inhibitors that have potential for treating obesity,diabetes and cancer.This review assesses the recent findings about the roles of SREBPs in the physiology of organs'function and pathogenesis of liver diseases.
