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Circulating and non-circulating proteins and nucleic acids as biomarkers and therapeutic molecules in ovarian cancer
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作者 Kumar Utkarsh Abhishek Kumar +4 位作者 Aditi azhar khan Ashima Nayyar Shabirul Haque Shams Iqbal 《Genes & Diseases》 SCIE CSCD 2023年第3期1005-1018,共14页
Ovarian cancer is the second most fatal gynecological cancer. For the last decade or so significant use of non-circulating and circulating biomarkers has been highlighted. However, the study of such biomarkers at nano... Ovarian cancer is the second most fatal gynecological cancer. For the last decade or so significant use of non-circulating and circulating biomarkers has been highlighted. However, the study of such biomarkers at nanovesicle technology such as exosomes, proteomic and genomics studies could further contribute to better identification of anomalous protein and networks which could act as potential targets for biomarker and immunotherapy development. This review provides an overview of the circulating and non-circulating biomarkers with the aim of addressing the current challenges and potential biomarkers that could lead to early ovarian cancer diagnosis and better management. By means of this review we also lay a hypothesis that characterization of exosomal protein, nucleic acid content from body fluids (serum, plasma, urine, etc.) can decode the secret of disease and potentially improve diagnostic sensitivity which could further lead to more effective screening and early detection of the disease. 展开更多
关键词 Biomarker Circulating protein EXOSOMES Extracellular vesicles Ovarian cancer Proteonnics
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