Objective:Carbophos(CAR)is an organophosphate that is most capable of producing free radicals and inducing alteration in some of the male reproductive parameters.Resveratrol(RES)is an herbal polyphenol and exerts bene...Objective:Carbophos(CAR)is an organophosphate that is most capable of producing free radicals and inducing alteration in some of the male reproductive parameters.Resveratrol(RES)is an herbal polyphenol and exerts beneficial antioxidant effects.This study aimed to evaluate the effects of RES against CAR-induced alteration in reproductive parameters of male rats.Methods:In this experimental study,48 male rats were randomly assigned to eight groups:Group 1:Normal control(saline)group;Group 2:CAR control(250 mg/kg)group;Groups 3-5:2,8,and 20 mg/kg RES,respectively,groups;Groups 6-8:CAR plus 2,8,and 20 mg/kg RES,respectively,groups.The agents were administered intraperitoneally and by gavage daily for 65 days.Sperm parameters,testis malondialdehyde(MDA)levels,total antioxidant capacity,testosterone levels,and germinal layer height were evaluated and compared among these groups.Results:No significant alterations were observed in RES groups(with different doses)compared to the normal control group(P>0.05).The levels of all parameters except MDA(which decreased)significantly increased in the CAR plus RES(with different doses)groups compared to the CAR control group(P<0.01).Conclusions:RES attenuates the toxic effect of CAR on some of the male reproductive parameters.展开更多
基金conducted in partial fulfillment of the requirements of an MD degree and was financially supported by the Research Council of the Kermanshah University of Medical Sciences,Kermanshah,I.R.Iran(Grant No.1397.306).
文摘Objective:Carbophos(CAR)is an organophosphate that is most capable of producing free radicals and inducing alteration in some of the male reproductive parameters.Resveratrol(RES)is an herbal polyphenol and exerts beneficial antioxidant effects.This study aimed to evaluate the effects of RES against CAR-induced alteration in reproductive parameters of male rats.Methods:In this experimental study,48 male rats were randomly assigned to eight groups:Group 1:Normal control(saline)group;Group 2:CAR control(250 mg/kg)group;Groups 3-5:2,8,and 20 mg/kg RES,respectively,groups;Groups 6-8:CAR plus 2,8,and 20 mg/kg RES,respectively,groups.The agents were administered intraperitoneally and by gavage daily for 65 days.Sperm parameters,testis malondialdehyde(MDA)levels,total antioxidant capacity,testosterone levels,and germinal layer height were evaluated and compared among these groups.Results:No significant alterations were observed in RES groups(with different doses)compared to the normal control group(P>0.05).The levels of all parameters except MDA(which decreased)significantly increased in the CAR plus RES(with different doses)groups compared to the CAR control group(P<0.01).Conclusions:RES attenuates the toxic effect of CAR on some of the male reproductive parameters.
