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The role of pro-inflammatory components, carcinoma-associated fibroblasts, and tumorassociated macrophages in ovarian cancer progression and metastasis
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作者 Josiany Carlos de Souza Roberto silva Ribeiro Junior +2 位作者 Tatiana Massariol Pimenta bárbara da silva martins Leticia batista Azevedo Rangel 《Journal of Cancer Metastasis and Treatment》 CAS 2023年第1期385-398,共14页
Ovarian cancer(OC)is associated with poor outcomes and challenges scientists and clinicians.It is usually diagnosed in advanced stages when it is frequently aggressive,chemoresistant,and metastatic.The most prevalent ... Ovarian cancer(OC)is associated with poor outcomes and challenges scientists and clinicians.It is usually diagnosed in advanced stages when it is frequently aggressive,chemoresistant,and metastatic.The most prevalent form of OC is epithelial ovarian cancer(EOC),which displays significant heterogeneity,enhancing the difficulty in managing the disease.Several factors have been associated with the disease’s development and progression,especially those related to the tumor microenvironment(TME).Here,we highlight components of the ovarian TME in the disease development process,including pro-inflammatory pathways activated by interleukins,cytokines and chemokines,cancer-associated fibroblasts,tumor-associated macrophages,and epithelial-mesenchymal transition.We compiled evidence identifying TME factors promoting the development,chemoresistance,and metastasis,including cytokines,chemokines,growth factors,and tumor-associated cells.We identify potential targets for treatment and improving outcomes.These targets block or alter pathways associated with OC(especially EOC)progression. 展开更多
关键词 CAFs INTERLEUKINS ovarian cancer TAMS tumor microenvironment
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