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Interference with the formation of the epididymal microenvironment——a new strategy for male contraception? 被引量:1
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作者 X.D.Gong G.P.H.Leung +1 位作者 b.l.y.cheuk P.Y.D.Wong 《Asian Journal of Andrology》 SCIE CAS CSCD 2000年第1期39-45,共7页
The cystic fibrosis transmembrane conductance regulator (CFIR) or the small conductance cAMP-activated chlo-ride channel encoded by the CFTR gene has been shown to play an important role in the formation of the epidid... The cystic fibrosis transmembrane conductance regulator (CFIR) or the small conductance cAMP-activated chlo-ride channel encoded by the CFTR gene has been shown to play an important role in the formation of the epididymalfluid microenvironment. Recent work in our laboratory has shown that this protein is also expressed by developing germcells indicating a role of this protein in spermatogenesis. In view of the fact that the CFTR gene has a far reaching andwidespread effect on human reproduction, understanding the role of CFTR in the male reproductive tissues and its inter-vention by pharmacological agents can open a new avenue of research into the development of novel male contracep-tives. (Asian J Androl 2000; 2: 39 - 45 ) 展开更多
关键词 EPIDIDYMIS CYCLOOXYGENASE CONTRACEPTION cystic fibrosis transmembrane conductance regulator
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