Due to interesting therapeutic properties of ^(153)Sm and antineoplastic antibiotic,bleomycin(BLM), ^(153)Sm-bleomycin(^(153)Sm-BLM) was developed as a possible therapeutic compound using ^(153)SmCl_3 and BLM.The ^(15...Due to interesting therapeutic properties of ^(153)Sm and antineoplastic antibiotic,bleomycin(BLM), ^(153)Sm-bleomycin(^(153)Sm-BLM) was developed as a possible therapeutic compound using ^(153)SmCl_3 and BLM.The ^(153)SmCl_3 was obtained by thermal neutron flux(5×10^(13)n·cm^(-2)·s^(-1))of an enriched ^(152)Sm_2O_3 sample,dissolved in acidic media.Under optimized conditions(room temperature,45 min,0.1 mg bleomycin for 740-3700 MBq ^(153)SmCl_3) a radiochemical purity over 98%was obtained shown by HPLC(Specific activity = 55 TBq/mM).The ^(153)SmCl_3 and ^(153)Sm-BLM were administered into wild-type rats up to 96 h followed by biodistribution.The SPECT imaging of labeled compound in wild-type rats was performed and significant image pattern was observed for a radiolabeled bleomycin compound.The ^(153)Sm-BLM is a potential therapeutic compound and our experiments on this compound have shown satisfactory quality,and stability suitable for future therapeutic studies.展开更多
基金support of the International Atomic Energy Agency(IAEA) support under IRA/2/006 and IRA/2/007
文摘Due to interesting therapeutic properties of ^(153)Sm and antineoplastic antibiotic,bleomycin(BLM), ^(153)Sm-bleomycin(^(153)Sm-BLM) was developed as a possible therapeutic compound using ^(153)SmCl_3 and BLM.The ^(153)SmCl_3 was obtained by thermal neutron flux(5×10^(13)n·cm^(-2)·s^(-1))of an enriched ^(152)Sm_2O_3 sample,dissolved in acidic media.Under optimized conditions(room temperature,45 min,0.1 mg bleomycin for 740-3700 MBq ^(153)SmCl_3) a radiochemical purity over 98%was obtained shown by HPLC(Specific activity = 55 TBq/mM).The ^(153)SmCl_3 and ^(153)Sm-BLM were administered into wild-type rats up to 96 h followed by biodistribution.The SPECT imaging of labeled compound in wild-type rats was performed and significant image pattern was observed for a radiolabeled bleomycin compound.The ^(153)Sm-BLM is a potential therapeutic compound and our experiments on this compound have shown satisfactory quality,and stability suitable for future therapeutic studies.
