目的:探讨九味镇心颗粒联合丙戊酸钠缓释片治疗双相情感障碍维持期的疗效。方法:选取2017年6月至2020年6月宁夏回族自治区宁安医院收治的双相情感障碍维持期患者92例,按随机数字表法分为对照组(46例)和研究组(46例)。对照组患者给予丙...目的:探讨九味镇心颗粒联合丙戊酸钠缓释片治疗双相情感障碍维持期的疗效。方法:选取2017年6月至2020年6月宁夏回族自治区宁安医院收治的双相情感障碍维持期患者92例,按随机数字表法分为对照组(46例)和研究组(46例)。对照组患者给予丙戊酸钠缓释片治疗,研究组患者在对照组的基础上给予九味镇心颗粒治疗,疗程均为2个月。观察两组患者的临床疗效,采用多导睡眠图检测睡眠情况,采用连线测验(trail making test,TMT)评估认知功能,采用生活质量综合评定问卷(generic quality of life inventory,GQL-LI)评定生活质量;记录治疗期间出现的不良反应。结果:研究组患者的临床总有效率为91.30%(42/46),明显高于对照组的73.91%(34/46),差异有统计学意义(P<0.05)。两组患者治疗后的睡眠效率明显高于治疗前,睡眠总时间、快速眼动睡眠时间明显长于治疗前,睡眠潜伏期、醒觉时间明显短于治疗前;且研究组患者的睡眠效率明显高于对照组,睡眠总时间、快速眼动睡眠睡眠时间明显长于对照组,睡眠潜伏期、醒觉时间明显短于对照组,差异均有统计学意义(P<0.05)。两组患者治疗后的TMT-A、TMT-B时间明显短于治疗前,GQL-LI评分明显高于治疗前;且研究组患者的TMT-A、TMT-B时间明显短于对照组,GQL-LI评分明显高于对照组,差异均有统计学意义(P<0.05)。对照组、研究组患者的不良反应发生率分别为19.57%(9/46)、8.70%(4/46),差异无统计学意义(P>0.05)。结论:九味镇心颗粒联合丙戊酸钠缓释片治疗双相情感障碍维持期的临床效果较佳,可改善患者睡眠质量,延长夜间睡眠时间,改善患者的认知功能,且安全性较高,可为临床治疗双相情感障碍维持期的患者提供参考方案。展开更多
The uniform nanoparticles PbS with diameters about 13 nm could be synthesized by Desulfotomaculum sp. under mild condition. The effects of the processing vari-ables such as pH and temperature were investigated. The ob...The uniform nanoparticles PbS with diameters about 13 nm could be synthesized by Desulfotomaculum sp. under mild condition. The effects of the processing vari-ables such as pH and temperature were investigated. The obtained products were in detailed by means of transmission electron microscopy(TEM) and X-ray diffraction(XRD) ,respectively. The results revealed that the PbS crystallites were identical in structure,shape and size under different temperatures while their morphology changed from rod to spheroidal with pH increasing. In the biological synthetic process for PbS nanoparticles,Desulfotomaculum sp. can use sulfate as a terminal electron acceptor to produce sulfide which acts as the source of sulfur for the formation of PbS nanoparticles.展开更多
文摘目的:探讨九味镇心颗粒联合丙戊酸钠缓释片治疗双相情感障碍维持期的疗效。方法:选取2017年6月至2020年6月宁夏回族自治区宁安医院收治的双相情感障碍维持期患者92例,按随机数字表法分为对照组(46例)和研究组(46例)。对照组患者给予丙戊酸钠缓释片治疗,研究组患者在对照组的基础上给予九味镇心颗粒治疗,疗程均为2个月。观察两组患者的临床疗效,采用多导睡眠图检测睡眠情况,采用连线测验(trail making test,TMT)评估认知功能,采用生活质量综合评定问卷(generic quality of life inventory,GQL-LI)评定生活质量;记录治疗期间出现的不良反应。结果:研究组患者的临床总有效率为91.30%(42/46),明显高于对照组的73.91%(34/46),差异有统计学意义(P<0.05)。两组患者治疗后的睡眠效率明显高于治疗前,睡眠总时间、快速眼动睡眠时间明显长于治疗前,睡眠潜伏期、醒觉时间明显短于治疗前;且研究组患者的睡眠效率明显高于对照组,睡眠总时间、快速眼动睡眠睡眠时间明显长于对照组,睡眠潜伏期、醒觉时间明显短于对照组,差异均有统计学意义(P<0.05)。两组患者治疗后的TMT-A、TMT-B时间明显短于治疗前,GQL-LI评分明显高于治疗前;且研究组患者的TMT-A、TMT-B时间明显短于对照组,GQL-LI评分明显高于对照组,差异均有统计学意义(P<0.05)。对照组、研究组患者的不良反应发生率分别为19.57%(9/46)、8.70%(4/46),差异无统计学意义(P>0.05)。结论:九味镇心颗粒联合丙戊酸钠缓释片治疗双相情感障碍维持期的临床效果较佳,可改善患者睡眠质量,延长夜间睡眠时间,改善患者的认知功能,且安全性较高,可为临床治疗双相情感障碍维持期的患者提供参考方案。
基金Supported by the Ministry of Science and Technology of the People’s Republic of China, and the Key Technologies R&D Program of China (Grant No. 2001BA540C)
文摘The uniform nanoparticles PbS with diameters about 13 nm could be synthesized by Desulfotomaculum sp. under mild condition. The effects of the processing vari-ables such as pH and temperature were investigated. The obtained products were in detailed by means of transmission electron microscopy(TEM) and X-ray diffraction(XRD) ,respectively. The results revealed that the PbS crystallites were identical in structure,shape and size under different temperatures while their morphology changed from rod to spheroidal with pH increasing. In the biological synthetic process for PbS nanoparticles,Desulfotomaculum sp. can use sulfate as a terminal electron acceptor to produce sulfide which acts as the source of sulfur for the formation of PbS nanoparticles.
